https://scholars.lib.ntu.edu.tw/handle/123456789/548534
標題: | Gender difference in the interaction effects of diabetes and hypertension on stroke among the elderly in the Shih-Pai study, Taiwan | 作者: | Lai Y.-J. HSI-CHUNG CHEN Chou P. |
公開日期: | 2015 | 卷: | 10 | 期: | 8 | 起(迄)頁: | e0136634 | 來源出版物: | PLoS ONE | 摘要: | Aims: To investigate the interaction effects of diabetes and hypertension on stroke, and also investigate the independent and interaction effects of parental history and environmental factors on diabetes and hypertension in a cross-sectional elderly population. Methods: The Shih-Pai Community Medical Service Program was a community-based, fixed cohort study conducted between June 1999 and November 2002. Socio-demographic and clinical data of subjects aged 65 years and older were collected by well-trained interviewers during home visits. Interaction effects were analyzed using Rothman's synergy index (SI). Results: In total, 4,124 subjects were included in the study, with 2,284 males and 1,840 females. The synergistic interaction of diabetes and hypertension on stroke was statistically significant in women (SI = 3.16, 95% CI: 1.35-7.39). The synergistic interaction of parental diabetes and being overweight on diabetes was only statistically significant in men, and not in women (SI = 3.30, 95% CI: 1.00-10.83 in men, and SI = 1.15, 95% CI: 0.30-4.39 in women). Conclusions: A synergistic interaction was found for diabetes and hypertension in both sexes when parental history and being overweight were combined. Furthermore, combining diabetes and hypertension in elderly women was significant in terms of the risk of stroke. Strategies to control risk factors in individuals at additional high risk are urgently needed. Copyright: ? 2015 Lai et al. |
URI: | 2-s2.0-84943302971 https://scholars.lib.ntu.edu.tw/handle/123456789/548534 |
ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0136634 | SDG/關鍵字: | aged; Article; assessment of humans; cerebrovascular accident; cohort analysis; community; controlled study; cross-sectional study; demography; diabetes mellitus; environmental factor; family history; female; human; hypertension; major clinical study; male; medical record; obesity; Rothman synergy index; sex difference; Taiwan; diabetes mellitus; hypertension; Overweight; questionnaire; risk factor; sex difference; Stroke; Aged; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Male; Overweight; Risk Factors; Sex Factors; Stroke; Surveys and Questionnaires; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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