https://scholars.lib.ntu.edu.tw/handle/123456789/548833
標題: | Acute respiratory infection and use of nonsteroidal anti-inflammatory drugs on risk of acute myocardial infarction: A nationwide case-crossover study | 作者: | Wen Y.-C. FEI-YUAN HSIAO KIN-WEI CHAN Lin Z.-F. LI-JIUAN SHEN CHENG-CHUNG FANG |
公開日期: | 2017 | 出版社: | Oxford University Press | 卷: | 215 | 期: | 4 | 起(迄)頁: | 503-509 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. Previous studies have suggested that acute respiratory infection (ARI) and nonsteroidal anti-inflammatory drugs (NSAIDs) use could trigger acute myocardial infarction (AMI). In some countries, physicians prescribe NSAIDs for patients with ARI for symptom relief. However, there is no research evaluating whether NSAIDs use during ARI episodes may increase the risk of AMI. Methods. We identified 9793 patients with an incident hospitalization of AMI (index date) between 2007 and 2011. Using case-crossover design, we compared the following exposure status between the case (17-day before index date) and matched control period (366372-day before index date): NSAIDs use during ARI episodes, ARI episodes without NSAIDs use, NSAIDs use only, or no exposure. Multivariable conditional logistic regression models were used to estimate odds ratios adjusted for potential confounders. Results. Nonsteroidal anti-inflammatory drugs use during ARI was associated with a 3.4-fold increased risk of AMI (adjusted odds ratio [aOR] = 3.41; 95% confidence interval [CI] = 2.804.16), ARI without NSAIDs use was associated with a 2.7-fold increased risk (aOR = 2.65; 95% CI = 2.293.06), and NSAIDs use only was associated with a 1.5-fold increased risk (aOR = 1.47; 95% CI = 1.331.62). Moreover, parenteral NSAIDs were associated with much higher risk in ARI patients (aOR = 7.22; 95% CI = 4.0712.81). Conclusions. Nonsteroidal anti-inflammatory drugs use during ARI episodes, especially parenteral NSAIDs, was associated with a further increased risk of AMI. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017013838&doi=10.1093%2finfdis%2fjiw603&partnerID=40&md5=2608c10126c3d5e2cdfc3a8402c58b42 https://scholars.lib.ntu.edu.tw/handle/123456789/548833 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jiw603 | SDG/關鍵字: | calcium channel blocking agent; nonsteroid antiinflammatory agent; nonsteroid antiinflammatory agent; acute heart infarction; adult; Article; cardiovascular risk; comorbidity; controlled study; diabetes mellitus; disease association; drug exposure; drug megadose; female; high risk patient; human; hypertension; low drug dose; major clinical study; male; respiratory tract infection; acute disease; aged; crossover procedure; hospitalization; middle aged; multivariate analysis; Myocardial Infarction; Respiratory Tract Infections; risk factor; statistical model; very elderly; Acute Disease; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Cross-Over Studies; Female; Hospitalization; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Respiratory Tract Infections; Risk Factors |
顯示於: | 腫瘤醫學研究所 |
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