https://scholars.lib.ntu.edu.tw/handle/123456789/548835
標題: | Risk of hip/femur fractures during the initiation period of α-adrenoceptor blocker therapy among elderly males: A self-controlled case series study | 作者: | CHAO LUN LAI Kuo, Raymond Nien-Chen Chen, Ho-Min MING-FONG CHEN KIN-WEI CHAN Lai, Mei-Shu |
關鍵字: | adrenergic α1-receptor antagonists; femoral fractures; hip fractures; self-controlled case series design | 公開日期: | 1-十一月-2015 | 出版社: | Blackwell Publishing Ltd | 卷: | 80 | 期: | 5 | 起(迄)頁: | 1208-1218 | 來源出版物: | British Journal of Clinical Pharmacology | 摘要: | Aims This study aimed to evaluate the risk of hip/femur fractures during the initiation period of α-adrenoceptor blocker therapy using the National Health Insurance claims database, Taiwan, with a self-controlled case series design. Methods All male beneficiaries aged over 50 years as of 2007, who were incident users of α-adrenoceptor blockers and also had a diagnosis of hip/femur fracture within the 2007-2009 study period were identified. The first day when the α-adrenoceptor blocker was prescribed was set as the index date. We partitioned the initial 21 day period following the index date as the post-exposure risk period 1, days 22-60 after the index date as the post-exposure risk period 2, the 21 day period prior to the index date as the pre-exposure risk period 1 and days 22-60 prior to the index date as the pre-exposure risk period 2. The remainder of the study period was defined as the unexposed period. The incidence rate ratio (IRR) of hip/femur fractures within each risk period compared with the unexposed period was estimated using a conditional Poisson regression model. Results A total of 5875 men were included. Compared with the unexposed period, the IRR of hip/femur fractures was 1.36 (95% confidence interval 1.06, 1.74, P = 0.017) within the post-exposure risk period 1 for patients without concomitant prescriptions of anti-hypertensive agents. Conclusions Use of α-adrenoceptor blockers was associated with a small but significant increase in the risk of hip/femur fractures during the early initiation period in patients without concomitant prescriptions of anti-hypertensive agents. © 2015 The British Pharmacological Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946082283&doi=10.1111%2fbcp.12671&partnerID=40&md5=2588bfd046cd433d61e3b0d0cdec03a3 https://scholars.lib.ntu.edu.tw/handle/123456789/548835 |
ISSN: | 0306-5251 | DOI: | 10.1111/bcp.12671 |
顯示於: | 腫瘤醫學研究所 |
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