https://scholars.lib.ntu.edu.tw/handle/123456789/550259
標題: | Mother-to-infant transmission of GB virus C/hepatitis G virus: The role of high-titered maternal viremia and mode of delivery | 作者: | HO-HSIUNG LIN JIA-HORNG KAO Yeh K.-Y. DING-PING LIU MEI-HWEI CHANG PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1998 | 出版社: | Oxford University Press | 卷: | 177 | 期: | 5 | 起(迄)頁: | 1202-1206 | 來源出版物: | Journal of Infectious Diseases | 摘要: | To study mother-to-infant transmission of GB virus C/hepatitis G virus (GBV-C/HGV), blood samples of infants born to carrier mothers were collected beginning 3 months after birth and were tested for GBV-C/HGV RNA until I year of age. Of 2046 mothers, 2.1% were positive for GBV-C/HGV RNA, and 25 of their infants were followed for a median of 12 months. Thirteen infants (52%) were viremic, and infection became persistent in all. Maternal GBV-C/HGV RNA levels of this group were > 107 copies/mL. Nucleotide sequence comparison in 5 viremic mother-infant pairs revealed a homology of 93%-98.2%, and none delivered by elective cesarean section. In comparison, of the 12 uninfected infants' mothers, 10 had lower GBV-C/HGV RNA levels (mean, 5 x 104 copies/mL), and the remaining 2 high-titered mothers had elective cesarean section. Thus, high-titered maternal viremia and mode of delivery are closely associated with the mother-to-infant transmission of GBV-C/HGV to infants, and the infection usually becomes persistent. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984535392&doi=10.1086%2f515264&partnerID=40&md5=dda83a8f354f30756d6dab77d4a529aa https://scholars.lib.ntu.edu.tw/handle/123456789/550259 |
ISSN: | 0022-1899 | DOI: | 10.1086/515264 | SDG/關鍵字: | virus RNA; adult; article; blood analysis; female; Hepatitis G virus; human; human cell; human tissue; infant; major clinical study; nucleotide sequence; phylogeny; placental transfer; priority journal; sequence homology; viremia; virus detection; virus transmission |
顯示於: | 醫學系 |
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