https://scholars.lib.ntu.edu.tw/handle/123456789/550285
標題: | Hepatitis C Virus Infection in Pregnant Women: Detection by Different Anti‐HCV Immunoassays and Serum HCV‐RNA | 作者: | HO-HSIUNG LIN HONG-YUAN HSU Lee T.-Y. JIA-HORNG KAO PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1994 | 卷: | 20 | 期: | 1 | 起(迄)頁: | 13-18 | 來源出版物: | Asia-Oceania Journal of Obstetrics and Gynaecology | 摘要: | Abstract To assess the seroepidemiology of hepatitis C virus (HCV) infection in pregnant women and explore the correlation between different anti?HCV immunoassays, we investigated 2 independent groups in Taipei: 1,687 pregnant women without screening for serum alanine aminotransferase (ALT) (group A) and 260 pregnant women with elevated ALT activity (>45 IU/1) screened from 15,978 cases (group B). In group A, 11 women (0.65%) were found to be anti?HCV?positive by first?generation tests and 21 (1.24%) by second?generation tests, while 7 (2.69%) and 15 (5.77%) of the group B subjects were positive, respectively. The results of the second?generation assays, based either on recombinant proteins or synthetic peptides, were identical. Among the 36 second?generation anti?HCV?positive cases, 18 (86%) of the 21 cases in group A and 13 (87%) of the 15 cases in group B contained serum HCV?RNA by RT?PCR. We conclude that the prevalence of anti?HCV in pregnant Taiwanese women is 1.24%, and the prevalence is 5.77% among those with an elevated ALT level. HCV?RNA is present in 86% of the cases positive for anti?HCV. The discrepancy between positive anti?HCV and negative HCV?RNA in some pregnant women suggests that anti?HCV positivity in such cases may merely represent a past HCV infection or a fluctuating viremia. ? 1994 Japanese Society of Obstetrics and Gynaecology |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028258737&doi=10.1111%2fj.1447-0756.1994.tb00414.x&partnerID=40&md5=4e3ecb8367f7ef9d4d75dc83747ff013 https://scholars.lib.ntu.edu.tw/handle/123456789/550285 |
ISSN: | 0389-2328 | DOI: | 10.1111/j.1447-0756.1994.tb00414.x | SDG/關鍵字: | adult; article; controlled study; female; hepatitis c; hepatitis c virus; human; immunoassay; major clinical study; polymerase chain reaction; pregnancy; taiwan; Female; Hepacivirus; Hepatitis Antibodies; Hepatitis C; Hepatitis C Antibodies; Human; Immunoenzyme Techniques; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; RNA, Viral; Support, Non-U.S. Gov't; Taiwan |
顯示於: | 醫學系 |
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