https://scholars.lib.ntu.edu.tw/handle/123456789/550604
Title: | Risk Factors and Genetic Biomarkers of Multiple Primary Cancers in Esophageal Cancer Patients | Authors: | Yang, Pei Wen MEI-CHUN LIN PEI-MING HUANG CHENG-PING WANG TSENG-CHENG CHEN Chun-Nan Chen MONG-HSUN TSAI CHIA-HSIEN CHENG Chuang, Eric Y. MIN-SHU HSIEH PEI-JEN LOU JANG-MING LEE |
Keywords: | esophageal cancer | head and neck cancer | multiple primary cancer | second primary cancer | single-nucleotide polymorphism;esophageal cancer; head and neck cancer; multiple primary cancer; second primary cancer; single-nucleotide polymorphism | Issue Date: | 22-Jan-2021 | Journal Volume: | 10 | Source: | Frontiers in Oncology | Abstract: | © Copyright © 2021 Yang, Lin, Huang, Wang, Chen, Chen, Tsai, Cheng, Chuang, Hsieh, Lou and Lee. Esophageal cancer (EC) is a deadly cancer that frequently develops multiple primary cancers (MPCs). However, the risk biomarkers of MPC in EC have hardly been investigated. We retrospectively enrolled 920 subjects with primary EC and analyzed the possible risk factors as well as MPC single-nucleotide polymorphisms (SNPs) from blood DNA. A total of 184 subjects (20.0%) were confirmed to have MPC, 59 (32.8%) had synchronous MPC, and 128 (69.6%) had head and neck cancer. Elderly EC patients have an increased risk of having gastrointestinal cancer (Odds ratio, OR[95% CI]=6.70 [1.49–30.19], p=0.013) and a reduced risk of developing HNC (OR[95% CI]=0.44 [0.24–0.81], p=0.008). MPC risk was also associated with betel nut chewing (OR[95% CI]=1.63, 1.14–2.32], p=0.008), the A allele of ALDH2:rs671 (p=0.074 and 0.030 for GA and AA, respectively), the CC genotype in CISH:rs2239751 (OR[95% CI]=1.99 [1.2–3.32], p=0.008), and the G allele of ERCC5:rs17655 (p=0.001 and 0.090 for GC and CC, respectively). ADH1B:rs1229984 also correlated with MPC risk (p=0.117). Patients carrying four risk SNPs had a 40-fold risk of MPC (OR[95% CI]=40.25 [6.77–239.50], p<0.001) and a 12.57-fold risk of developing second primary cancer after EC (OR[95% CI]=12.57 [1.14–138.8], p=0.039) compared to those without any risk SNPs. In conclusion, hereditary variations in ALDH2, CISH, ERCC5, and ADH1B have great potential in predicting the incidence of MPC in EC patients. An extensive cancer screening program during clinical follow-up would be beneficial for patients with high MPC susceptibility. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/550604 | DOI: | 10.3389/fonc.2020.585621 | SDG/Keyword: | alcohol dehydrogenase 1b; aldehyde dehydrogenase; ERCC 5 protein; oxidoreductase; protein tyrosine phosphatase SHP; suppressor of cytokine signaling; transcription factor; unclassified drug; adult; alcohol consumption; areca nut; Article; cancer patient; cancer risk; cancer staging; cancer susceptibility; chemoradiotherapy; cigarette smoking; computer assisted tomography; digestive system cancer; DNA extraction; endoscopic ultrasonography; esophagus cancer; female; follow up; genetic marker; genotype; genotyping technique; head and neck cancer; human; inflammation; major clinical study; male; mastication; middle aged; multiple cancer; neoadjuvant chemotherapy; nucleotide excision repair; receiver operating characteristic; retrospective study; risk factor; second cancer; sensitivity and specificity; single nucleotide polymorphism; tumor localization |
Appears in Collections: | 醫學系 |
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