https://scholars.lib.ntu.edu.tw/handle/123456789/550732
標題: | Curation of cancer hallmark-based genes and pathways for in silico characterization of chemical carcinogenesis | 作者: | Liang, P.-I. CHIA-CHI WANG Cheng, H.-J. Wang, S.-S. Lin, Y.-C. Lin, P. Tung, C.-W. |
關鍵字: | cancer hallmark; curation; the Halifax Project | 公開日期: | 2020 | 卷: | 2020 | 來源出版物: | Database : the journal of biological databases and curation | 摘要: | Exposure to toxic substances in the environment is one of the most important causes of cancer. However, the time-consuming process for the identification and characterization of carcinogens is not applicable to a huge amount of testing chemicals. The data gaps make the carcinogenic risk uncontrollable. An efficient and effective way of prioritizing chemicals of carcinogenic concern with interpretable mechanism information is highly desirable. This study presents a curation work for genes and pathways associated with 11 hallmarks of cancer (HOCs) reported by the Halifax Project. To demonstrate the usefulness of the curated HOC data, the interacting HOC genes and affected HOC pathways of chemicals of the three carcinogen lists from IARC, NTP and EPA were analyzed using the in silico toxicogenomics ChemDIS system. Results showed that a higher number of affected HOCs were observed for known carcinogens than the other chemicals. The curated HOC data is expected to be useful for prioritizing chemicals of carcinogenic concern. Database URL: The HOC database is available at https://github.com/hocdb-KMU-TMU/hocdb and the website of Database journal as Supplementary Data. ? 2020 The Author(s) 2020. Published by Oxford University Press. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85086624390&partnerID=40&md5=85aa174be9c70d485f648646e352e9c1 https://scholars.lib.ntu.edu.tw/handle/123456789/550732 |
DOI: | 10.1093/database/baaa045 | SDG/關鍵字: | carcinogen; carcinogenesis; classification; computer simulation; drug effect; factual database; genetics; human; information processing; neoplasm; toxicogenetics; tumor gene; Carcinogenesis; Carcinogens; Computer Simulation; Data Curation; Databases, Factual; Genes, Neoplasm; Humans; Neoplasms; Toxicogenetics |
顯示於: | 獸醫學系 |
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