https://scholars.lib.ntu.edu.tw/handle/123456789/550747
標題: | Autologous mitochondrial microinjection; A strategy to improve the oocyte quality and subsequent reproductive outcome during aging | 作者: | Mobarak, H. Heidarpour, M. PEI-SHIUE TSAI Rezabakhsh, A. Rahbarghazi, R. Nouri, M. Mahdipour, M. |
關鍵字: | Ageing; Mitochondrial transfer; Oocyte quality; Reproduction | 公開日期: | 2019 | 卷: | 9 | 期: | 1 | 來源出版物: | Cell and Bioscience | 摘要: | Along with the decline in oocyte quality, numerous defects such as mitochondrial insufficiency and the increase of mutation and deletion have been reported in oocyte mitochondrial DNA (mtDNA) following aging. Any impairments in oocyte mitochondrial function have negative effects on the reproduction and pregnancy outcome. It has been stated that infertility problems caused by poor quality oocytes in women with in vitro fertilization (IVF) and repeated pregnancy failures are associated with aging and could be overcome by transferring large amounts of healthy mitochondria. Hence, researches on biology, disease, and the therapeutic use of mitochondria continue to introduce some clinical approaches such as autologous mitochondrial transfer techniques. Following mitochondrial transfer, the amount of ATP required for aged-oocyte during fertilization, blastocyst formation, and subsequent embryonic development could be an alternative modality. These modulations improve the pregnancy outcome in women of high reproductive aging as well. In addition to overview the clinical studies using mitochondrial microinjection, this study provides a framework for future approaches to develop effective treatments and preventions of congenital transmission of mitochondrial DNA mutations/diseases to offspring. Mitochondrial transfer from ovarian cells and healthy oocytes could lead to improved fertility outcome in low-quality oocytes. The modulation of mitochondrial bioactivity seems to regulate basal metabolism inside target oocytes and thereby potentiate physiological activity of these cells while overcoming age-related infertility in female germ cells. ? 2019 The Author(s). |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85075821470&partnerID=40&md5=f85dbe7be913f1c69a1b0a0e50ee5c24 https://scholars.lib.ntu.edu.tw/handle/123456789/550747 |
DOI: | 10.1186/s13578-019-0360-5 | SDG/關鍵字: | mitochondrial DNA; aging; autotransplantation; basal metabolic rate; biological activity; blastomere; cell activity; cell nucleus transplantation; cell transfer; cytoplasm; gene mutation; germ cell; human; in vitro fertilization; microinjection; mitochondrion; oocyte; ovary cell line; pregnancy disorder; pregnancy outcome; regulatory mechanism; reproductive procedure; Review |
顯示於: | 獸醫學系 |
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