https://scholars.lib.ntu.edu.tw/handle/123456789/550891
標題: | Mucosal intralymphatic spread in a relapsed diffuse large B cell lymphoma | 作者: | SHAN-CHI YU CHANG-TSU YUAN |
關鍵字: | Diffuse large B cell lymphoma; Endoscopic biopsy; Intralymphatic spread; INTRAVASCULAR LYMPHOMA; MYC REARRANGEMENT; CLASSIFICATION; EXPRESSION; BCL2 | 公開日期: | 2020 | 出版社: | SPRINGER HEIDELBERG | 卷: | 13 | 期: | 3 | 起(迄)頁: | 179 | 來源出版物: | JOURNAL OF HEMATOPATHOLOGY | 摘要: | © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Intralymphatic spread is a rare finding and is associated with poor prognosis in diffuse large B cell lymphoma (DLBCL). Here, we report a case of relapsed DLBCL with mucosal intralymphatic spread. A 69-year-old man had been diagnosed with gastric DLBCL stage IIE at 57 years. He had a relapse with generalized lymphadenopathy and extranodal involvement at 61 years; then, second complete remission was achieved after salvage chemotherapy. He then had a second relapse with involvement of the terminal ileum, spinal cord, and left tonsil. The terminal ileum showed intralymphatic spread in the lamina propria of the intestinal villi, which was confirmed by D2–40 immunostaining. Eleven months later, another biopsy showed prominent intralymphatic spread in the mucosa of the terminal ileum. After salvage therapies, the spinal cord and tonsillar tumors resolved, but the intestinal tumors were refractory. The patient eventually died of progressive disease. In contrast to previously reported cases, the involved lymphatic vessels were observed in the mucosa, and the lymphoma cells expressed CD5 in the first colonoscopic biopsy. This rare case broadens the spectrum of intralymphatic spread in DLBCL. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/550891 | ISSN: | 1868-9256 | DOI: | 10.1007/s12308-020-00403-x | SDG/關鍵字: | CD20 antigen; CD5 antigen; common acute lymphoblastic leukemia antigen; cyclin D1; etoposide; interferon regulatory factor 4; lactate dehydrogenase; Myc protein; polatuzumab vedotin; protein bcl 2; protein bcl 6; transcription factor PAX5; transcription factor Sox11; abdominal pain; adult; aged; algorithm; Article; body weight loss; case report; chromoendoscopy; clinical article; colonoscopy; diffuse large B cell lymphoma; endoscopy; follow up; Helicobacter; human; human tissue; in situ hybridization; intestine villus; lamina propria; lymphadenopathy; lymphoma cell; male; malignant neoplasm; mucosal intralymphatic spread; occult blood; positron emission tomography; priority journal; remission; spinal cord cancer; stomach biopsy; stomach muscle; tenesmus; terminal ileum; ulcerative colitis |
顯示於: | 病理學科所 |
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