https://scholars.lib.ntu.edu.tw/handle/123456789/550978
標題: | Clinicopathological study of intraductal carcinoma of the salivary gland, with emphasis on the apocrine type | 作者: | MIN-SHU HSIEH Lee Y.-H. Jin Y.-T. Kuo Y.-J. |
關鍵字: | HER2; HRAS; Intraductal carcinoma of the salivary gland; PIK3CA; Salivary duct carcinoma | 公開日期: | 2020 | 出版社: | Springer Science and Business Media Deutschland GmbH | 卷: | 477 | 期: | 4 | 起(迄)頁: | 581-592 | 來源出版物: | Virchows Archiv | 摘要: | Intraductal carcinoma (IC) is a rare salivary gland tumor with low- to intermediate-grade cytological features. It is further classified into intercalated duct type and apocrine type based on its distinct histologic and immunohistochemical expression. Conventional salivary duct carcinoma (SDC) is an aggressive carcinoma with high-grade features and is usually associated with poor prognosis. In this study, immunohistochemistry and mutation analyses (including HRAS/PIK3CA mutations, RET rearrangement, and human epidermal growth factor receptor 2 [HER2] amplification) of 9 ICs (including 3 pure ICs, 6 ICs with invasive carcinoma) and 24 conventional SDCs were performed and the results were compared. Four intercalated duct-type cases were positive for SOX10 and S100 and negative for AR; five apocrine-type cases showed opposite results. All five apocrine-type cases had cysts with relatively circumscribed tumor borders and morphologically mimicking breast low-grade ductal carcinoma in situ or papillary carcinoma. RET fusion is detected in half of the 4 intercalated duct-type IC but not in the apocrine-type or conventional SDC. HER2 amplification was only observed in conventional SDC. The monoclonal antibody (clone RBT-NRAS) against NRAS Q61R is a sensitive and specific marker used for detecting HRAS Q61R mutation in the salivary gland tumors. The apocrine-type IC had different cytological grades, distinct tumor growth patterns, and no evidence of low- to high-grade transition, suggesting that apocrine-type IC should be distinguished from apocrine SDC with an in situ component. ? 2020, Springer-Verlag GmbH Germany, part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085078254&doi=10.1007%2fs00428-020-02823-7&partnerID=40&md5=fe54c9dd87e0efece6f83d63b803dc1b https://scholars.lib.ntu.edu.tw/handle/123456789/550978 |
ISSN: | 0945-6317 | DOI: | 10.1007/s00428-020-02823-7 | SDG/關鍵字: | epidermal growth factor receptor 2; mammaglobin; monoclonal antibody; protein Ret; protein S 100; transcription factor Sox10; tumor marker; adult; aged; antigen retrieval; Article; cancer diagnosis; clinical article; comparative study; controlled study; cystadenocarcinoma; female; fluorescence in situ hybridization; fusion gene; gene mutation; gene rearrangement; human; immunohistochemistry; intraductal carcinoma; male; middle aged; oncogene N ras; papillary carcinoma; priority journal; salivary duct carcinoma; Sanger sequencing; tumor growth; tumor recurrence; tumor volume; very elderly; cancer grading; cell proliferation; chemistry; cystadenocarcinoma; differential diagnosis; dna mutational analysis; gene amplification; genetic predisposition; genetics; mutation; Paget nipple disease; pathology; phenotype; predictive value; salivary gland tumor; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Ductal; Cell Proliferation; Cystadenocarcinoma; Diagnosis, Differential; DNA Mutational Analysis; Female; Gene Amplification; Gene Rearrangement; Genetic Predisposition to Disease; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Middle Aged; Mutation; Neoplasm Grading; Phenotype; Predictive Value of Tests; Salivary Gland Neoplasms |
顯示於: | 病理學科所 |
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