https://scholars.lib.ntu.edu.tw/handle/123456789/551045
標題: | Pathologic findings of patients with nonalcoholic fatty liver disease and the impact of concurrent hepatitis B virus infection in Taiwan | 作者: | Su H.-J. JIA-HORNG KAO TAI-CHUNG TSENG HUNG-CHIH YANG TUNG-HUNG SU PEI-JER CHEN CHUN-JEN LIU |
公開日期: | 2020 | 出版社: | Elsevier B.V. | 卷: | 119 | 期: | 10 | 起(迄)頁: | 1476-1482 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background & aims: Pathologic data of non-alcoholic fatty liver disease (NAFLD) was limited and the association between NAFLD and chronic hepatitis B remained unclear in Taiwan. This study aimed to determine the pathological manifestations of NAFLD and the impact of concurrent hepatitis B virus (HBV) infection in a medical center. Methods: Retrospective review of 104 consecutive random liver biopsies with the histologic diagnosis of NAFLD or cryptogenic cirrhosis from 2009 to 2018 was conducted. Clinical, biochemical and histological data were compared among various stages of NAFLD and between those with or without concurrent HBV infection. Results: Advanced fibrosis was documented in 39.42% of Taiwanese patients with NAFLD according to METAVIR scoring system and was associated with aging (odds ratio, 1.06; 95% CI, 1.03–1.10), hypertension (odds ratio, 2.97; 95% CI, 1.31–6.74), diabetes mellitus (odds ratio, 4.36; 95% CI, 1.78–10.70) and concurrent HBV infection (odds ratio, 3.55; 95% CI, 1.46–8.58) by multivariate analyses. Concurrent HBV was found in 28.57% of the NAFLD patients. Patients with concurrent HBV had lower platelet counts, longer prothrombin time/INR and higher fibrosis stage than those without CHB. Conclusion: Advanced fibrosis in patients with NAFLD was common in the biopsy series, and was related to aging, hypertension, diabetes mellitus and concurrent HBV infection. ? 2020 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085636647&doi=10.1016%2fj.jfma.2020.05.027&partnerID=40&md5=67b4681ca1bf42ce1f3428c1fbeb05e2 https://scholars.lib.ntu.edu.tw/handle/123456789/551045 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2020.05.027 | SDG/關鍵字: | hepatitis B(e) antigen; adult; aging; antigen blood level; Article; clinical feature; controlled study; cross-sectional study; diabetes mellitus; disease association; dyslipidemia; female; hepatitis B; histopathology; human; human tissue; hypertension; international normalized ratio; liver biopsy; liver cirrhosis; major clinical study; male; middle aged; nonalcoholic fatty liver; platelet count; predictive value; prothrombin time; retrospective study; Taiwan; virus load; complication; hepatitis B; Hepatitis B virus; liver cirrhosis; nonalcoholic fatty liver; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease; Retrospective Studies; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。