https://scholars.lib.ntu.edu.tw/handle/123456789/551115
標題: | Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU CHI-LING CHEN Yang W.-T HUNG-CHIH YANG TUNG-HUNG SU Wang C.-C Kuo S.F.-T CHEN-HUA LIU PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2015 | 出版社: | Blackwell Publishing Ltd | 卷: | 41 | 期: | 10 | 起(迄)頁: | 949-960 | 來源出版物: | Alimentary Pharmacology and Therapeutics | 摘要: | Background Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss. Methods We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg-negative patients. HBV pre-core stop codon (1896) and basal core promoter (BCP) (1762/1764) sequences were determined in patients with HBV DNA ?200 IU/mL (N = 1693). The effect of HBV genotype on HBsAg loss was further validated in the whole cohort of 3445 HBsAg carriers. Results The cumulative lifetime (age 28-75 years) incidence of HBsAg loss was 50.4% in 2121 HBeAg-negative patients. We found that genotype C, but not pre-core stop codon or BCP mutants, was associated with HBsAg loss. Compared to genotype B patients, genotype C patients had higher lifetime chance of HBsAg loss, with hazard ratio of 1.8 (95% confidence interval: 1.4-2.4). Multivariable analysis showed that male sex, elevated ALT levels, lower serum HBV DNA and HBsAg levels, and genotype C infection were associated with higher chance of HBsAg loss independently. We then performed sensitivity analysis, which re-included HBeAg-positive, cirrhotic and treatment-experienced patients, and confirmed the robustness of our results in 3445 HBsAg carriers. Conclusion Genotype C infection, compared to genotype B, is associated with a higher lifetime chance of HBsAg loss in Asian HBV carriers. ? 2015 John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927747510&doi=10.1111%2fapt.13170&partnerID=40&md5=861799614254ebef84f1f9035ea0a7f7 https://scholars.lib.ntu.edu.tw/handle/123456789/551115 |
ISSN: | 0269-2813 | DOI: | 10.1111/apt.13170 | SDG/關鍵字: | hepatitis B surface antigen; hepatitis B surface antigen; virus DNA; adult; age distribution; aged; Article; controlled study; disease association; DNA determination; female; gene sequence; hepatitis B; Hepatitis B virus genotype B; Hepatitis B virus genotype C; human; lifespan; liver cirrhosis; major clinical study; male; middle aged; priority journal; prognosis; promoter region; risk assessment; stop codon; virus carrier; blood; cohort analysis; follow up; genetics; genotype; hepatitis B; Hepatitis B virus; heterozygote; incidence; virology; Adult; Aged; Carrier State; Cohort Studies; DNA, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Incidence; Male; Middle Aged |
顯示於: | 醫學系 |
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