https://scholars.lib.ntu.edu.tw/handle/123456789/551132
標題: | Host Genetic Factors Affecting Spontaneous HBsAg Seroclearance in Chronic Hepatitis B Patients | 作者: | Cheng H.-R. CHUN-JEN LIU TAI-CHUNG TSENG TUNG-HUNG SU Yang H.-I. Chen C.-J. JIA-HORNG KAO |
公開日期: | 2013 | 卷: | 8 | 期: | 1 | 來源出版物: | PLoS ONE | 摘要: | Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2 SNPs on spontaneous HBsAg clearance in CHB patients. In this case-control study, a total of 100 male HBeAg-negative chronic HBV carriers who cleared HBsAg spontaneously (case group) and 100 age-matched HBeAg-negative male patients with persistent HBsAg positivity (control group) were enrolled. We investigated the relationship between these 2 SNPs and HBsAg clearance. There was a higher frequency of rs9277535 non-GG genotype in the case group (57% vs. 42%). Patients with rs9277535 non-GG genotype had a higher chance to clear HBsAg [Odds ratio (OR): 1.83, 95% confidence interval (CI): 1.04~3.21, P = 0.034]. Compared to GG haplotype of rs3077 and rs9277535, GA haplotype had a higher chance of achieving spontaneous HBsAg loss (OR: 2.17, 95% CI: 1.14~4.16, P = 0.030). In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients. ? 2013 Cheng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872256276&doi=10.1371%2fjournal.pone.0053008&partnerID=40&md5=d31920f1a247d26e639a6e6b4ce7743f https://scholars.lib.ntu.edu.tw/handle/123456789/551132 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0053008 | SDG/關鍵字: | genomic DNA; hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; adult; article; case control study; controlled study; genetic association; genotype; haplotype; hepatitis B; human; major clinical study; male; plasma clearance; real time polymerase chain reaction; single nucleotide polymorphism; virus carrier; virus cell interaction; virus load; Case-Control Studies; Cohort Studies; Gene Frequency; Genotype; Haplotypes; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HLA-DP alpha-Chains; HLA-DP beta-Chains; Host-Pathogen Interactions; Humans; Linkage Disequilibrium; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Hepatitis B virus |
顯示於: | 醫學系 |
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