https://scholars.lib.ntu.edu.tw/handle/123456789/551134
標題: | Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU HUNG-CHIH YANG TUNG-HUNG SU Wang C.-C CHI-LING CHEN Hsu C.-A Fang-Tzu Kuo S CHEN-HUA LIU PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2013 | 出版社: | John Wiley and Sons Inc. | 卷: | 57 | 期: | 2 | 起(迄)頁: | 441-450 | 來源出版物: | Hepatology | 摘要: | Chronic hepatitis B patients with high viral loads are at increased risk of cirrhosis and hepatocellular carcinoma (HCC). In patients with low viral loads, higher hepatitis B surface antigen (HBsAg) levels have been shown to predict HCC development. However, little is known about the difference in risk for other hepatitis B virus (HBV)-related adverse outcomes with varying HBsAg levels. A total of 1,068 Taiwanese hepatitis B e antigen (HBeAg)-negative HBV carriers with serum HBV DNA level <2,000 IU/mL at baseline were followed for a mean duration of 13.0 years. Patients were categorized based on their HBsAg levels, and the relationships between HBsAg level and development of HBeAg-negative hepatitis, hepatitis flare, and cirrhosis were investigated. Of the 1068 patients with low viral loads, 280 developed HBeAg-negative hepatitis, with an annual incidence rate of 2.0%. HBsAg level, but not HBV DNA level, was found to be a risk factor for HBeAg-negative hepatitis. Multivariate analysis showed that the adjusted hazard ratio in patients with an HBsAg level ?1,000 versus <1000 IU/mL was 1.5 (95% confidence interval, 1.2-1.9). The positive correlation was present when evaluating other endpoints, including hepatitis flare and cirrhosis, and remained consistent when the study population was restricted to those with normal alanine aminotransferase (ALT) level at baseline. The annual incidence rate of HBeAg-negative hepatitis was lowered to 1.1% in patients with low levels of HBV DNA, HBsAg, and ALT. Conclusion: In HBeAg-negative patients with low viral loads and genotype B or C virus infection, a higher HBsAg level can predict disease progression. HBsAg <1,000 IU/mL in combination with low levels of HBV DNA and ALT help define minimal-risk HBV carriers. ? 2012 American Association for the Study of Liver Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984578046&doi=10.1002%2fhep.26041&partnerID=40&md5=13af8089dd3cdae4a041935d0837a6bb https://scholars.lib.ntu.edu.tw/handle/123456789/551134 |
ISSN: | 0270-9139 | DOI: | 10.1002/hep.26041 | SDG/關鍵字: | hepatitis B surface antigen; adult; article; controlled study; disease course; disease exacerbation; female; follow up; hepatitis B; human; major clinical study; male; priority journal; prognosis; Taiwan; virus load |
顯示於: | 醫學系 |
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