https://scholars.lib.ntu.edu.tw/handle/123456789/551138
標題: | Host genetic variants and hepatitis b virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission | 作者: | Lin C.-L. TAI-CHUNG TSENG TUNG-HUNG SU CHUN-JEN LIU PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2012 | 出版社: | Springer New York LLC | 卷: | 6 | 期: | 3 | 起(迄)頁: | 598-605 | 來源出版物: | Hepatology International | 摘要: | Purpose A significant portion of HBeAg-negative chronic hepatitis B patients have persistently normal serum alanine aminotransferase levels (PNALT). We thus investigated host genetic variants and virological features in HBeAg-negative hepatitis B carriers. Methods Baseline clinical and virological features of 133 HBeAg-negative hepatitis B carriers (77 with PNALT and 56 with chronic hepatitis activity) with follow-up for more than 5 years were investigated. Three single nucleotide polymorphisms (SNPs) located within or around human leukocyte antigen (HLA)-DPA1, HLA-DPB1, and interleukin (IL) 28B loci were genotyped. Results The genotype frequencies of these SNPs were comparable between hepatitis B carriers with PNALT and those with chronic hepatitis. Compared with hepatitis B carriers with PNALT, those with chronic hepatitis had significantly higher baseline serum HBV-DNA levels (4.96 vs. 4.04 log10 IU/ml, P = 0.001). Baseline serum HBV-DNA level >2000 IU/ml (OR, 8.42; 95% CI, 2.74-25.90, P<0.001) were the only independent factor associated with chronic hepatitis activity. Changes of serum HBV-DNA in 30 hepatitis B carriers with PNALT had showed a significant reduction of viral load frombaseline to last visit (mean difference of paired HBV-DNA levels:-0.78 log10 IU/ml, 95%CI:-1.57 to -0.013, P = 0.047). In contrast, no significant reduction of viral load was found in 28 patients with chronic hepatitis. Conclusions The results indicate that lower baseline serum HBV-DNA level and viral load reduction over time are associated with long-term biochemical remission in HBeAg-negative hepatitis B carriers. ? Asian Pacific Association for the Study of the Liver 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984565011&doi=10.1007%2fs12072-011-9297-4&partnerID=40&md5=c14f5a8ada1478874b2cc0b98690867b https://scholars.lib.ntu.edu.tw/handle/123456789/551138 |
ISSN: | 1936-0533 | DOI: | 10.1007/s12072-011-9297-4 | SDG/關鍵字: | alanine aminotransferase; hepatitis B(e) antigen; HLA DPB1 antigen; interleukin 28B; virus DNA; adult; aged; alanine aminotransferase blood level; allele; article; biochemistry; clinical feature; female; follow up; gene; gene frequency; genetic variability; genotype; hepatitis B; Hepatitis B virus; HLA DPA1 gene; HLA DPB1 gene; human; IL28B gene; major clinical study; male; polymorphic locus; priority journal; remission; single nucleotide polymorphism; virus carrier; virus load |
顯示於: | 醫學系 |
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