https://scholars.lib.ntu.edu.tw/handle/123456789/551139
標題: | Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU CHI-LING CHEN Wang C.-C. TUNG-HUNG SU Kuo S.F.-T. PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2012 | 出版社: | Oxford University Press | 卷: | 205 | 期: | 1 | 起(迄)頁: | 54-63 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. Hepatitis B e antigen (HBeAg) status and serum hepatitis B virus (HBV) DNA levels are major factors affecting the prognosis of adult HBV carriers; however, the impact of viral load on long-term outcomes after spontaneous HBeAg seroconversion remains unclear. Methods. A total of 390 spontaneous HBeAg seroconverters with a long-term follow-up were enrolled. Serum HBV-DNA levels at 1 year after HBeAg seroconversion were determined, and their correlation with long-term adverse outcomes was explored. Results. In a mean follow-up of 6.8 years, the average annual incidence rates were 4.4% and 1.9% for HBeAg-negative hepatitis and hepatitis flare, respectively. Compared with patients with HBV-DNA levels <200 IU/mL, the adjusted hazard ratios of HBeAg-negative hepatitis were 2.4 (95% confidence interval, 1.3-4.4), 3.6 (1.8-7.2), and 5.3 (2.8-10.0), respectively, for serum HBV-DNA level of 2000-2 × 104, 2 × 104-2 × 105, and ?2 × 105 IU/mL. In addition, serum HBV-DNA levels were independently associated with HBeAg-negative hepatitis flare, which confirmed their impact on the immune active hepatitis after HBeAg seroconversion. Conclusions.HBeAg seroconversion may not always confer favorable outcomes. Serum HBV-DNA levels ?2000 IU/mL at 1 year post HBeAg seroconversion correlate with increased risk of HBeAg-negative hepatitis and hepatitis flare. ? 2011 The Author. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983727403&doi=10.1093%2finfdis%2fjir687&partnerID=40&md5=ea071f1c68a87961df3b438dab61321d https://scholars.lib.ntu.edu.tw/handle/123456789/551139 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jir687 | SDG/關鍵字: | alanine aminotransferase; hepatitis B(e) antigen; virus DNA; adult; adverse outcome; alanine aminotransferase blood level; article; cohort analysis; disease course; disease exacerbation; female; follow up; hepatitis B; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; pilot study; priority journal; prognosis; seroconversion |
顯示於: | 醫學系 |
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