https://scholars.lib.ntu.edu.tw/handle/123456789/551139
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | TAI-CHUNG TSENG | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | CHI-LING CHEN | en_US |
dc.contributor.author | Wang C.-C. | en_US |
dc.contributor.author | TUNG-HUNG SU | en_US |
dc.contributor.author | Kuo S.F.-T. | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.date.accessioned | 2021-03-09T01:47:45Z | - |
dc.date.available | 2021-03-09T01:47:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983727403&doi=10.1093%2finfdis%2fjir687&partnerID=40&md5=ea071f1c68a87961df3b438dab61321d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/551139 | - |
dc.description.abstract | Background. Hepatitis B e antigen (HBeAg) status and serum hepatitis B virus (HBV) DNA levels are major factors affecting the prognosis of adult HBV carriers; however, the impact of viral load on long-term outcomes after spontaneous HBeAg seroconversion remains unclear. Methods. A total of 390 spontaneous HBeAg seroconverters with a long-term follow-up were enrolled. Serum HBV-DNA levels at 1 year after HBeAg seroconversion were determined, and their correlation with long-term adverse outcomes was explored. Results. In a mean follow-up of 6.8 years, the average annual incidence rates were 4.4% and 1.9% for HBeAg-negative hepatitis and hepatitis flare, respectively. Compared with patients with HBV-DNA levels <200 IU/mL, the adjusted hazard ratios of HBeAg-negative hepatitis were 2.4 (95% confidence interval, 1.3-4.4), 3.6 (1.8-7.2), and 5.3 (2.8-10.0), respectively, for serum HBV-DNA level of 2000-2 × 104, 2 × 104-2 × 105, and ?2 × 105 IU/mL. In addition, serum HBV-DNA levels were independently associated with HBeAg-negative hepatitis flare, which confirmed their impact on the immune active hepatitis after HBeAg seroconversion. Conclusions.HBeAg seroconversion may not always confer favorable outcomes. Serum HBV-DNA levels ?2000 IU/mL at 1 year post HBeAg seroconversion correlate with increased risk of HBeAg-negative hepatitis and hepatitis flare. ? 2011 The Author. | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | Journal of Infectious Diseases | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; hepatitis B(e) antigen; virus DNA; adult; adverse outcome; alanine aminotransferase blood level; article; cohort analysis; disease course; disease exacerbation; female; follow up; hepatitis B; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; pilot study; priority journal; prognosis; seroconversion | - |
dc.title | Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/infdis/jir687 | - |
dc.identifier.scopus | 2-s2.0-84983727403 | - |
dc.relation.pages | 54-63 | en_US |
dc.relation.journalvolume | 205 | en_US |
dc.relation.journalissue | 1 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Research | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0002-6747-7941 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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