|Title:||The clinical significance of occult hepatitis B transfusion in Taiwan - a look-back study||Authors:||TUNG-HUNG SU
|Issue Date:||2011||Publisher:||Blackwell Publishing Ltd||Journal Volume:||21||Journal Issue:||1||Start page/Pages:||33-41||Source:||Transfusion Medicine||Abstract:||
Objectives: A look-back study was conducted to determine the clinical significance of occult hepatitis B virus (HBV) blood transfusion in an HBV hyperendemic area. Aim: To improve the blood transfusion safety. Background: Occult HBV is transmissible through blood transfusion in HBV-na?ve recipients. However, its impact on recipients with prevalent HBV infection in HBV hyperendemic areas is unclear. Methods/Materials: In 2006, 12 occult HBV blood donors were found from 10 824 repository samples by nucleic acid testing. The 74 corresponding recipients were identified and their pre- and post-transfusion clinical information was gathered, and the living recipients were recalled for follow-up. From the available archival sera, the HBV DNA was examined and sub-genomic sequences between paired donor and recipient were compared using polymerase chain reaction-based assays. Results: Among the 74 recipients, 18 were still alive and 12 returned to our clinic. From the available serological profiles, 76% of recipients had ongoing or recovered HBV infection before transfusion. Only 24 recipients had available post-transfusion serological profiles and none seroconverted to be hepatitis B surface antigen (HBsAg) positive. Moreover, except for the prior HBsAg carriers, the recipients' HBV DNA levels after transfusion were low (<20 IU/mL). One recipient had identical HBV surface gene sub-genomic sequence (384 nucleotides) to his donor. After transfusion, no recipient developed post-transfusion hepatitis (PTH) and the clinical outcome was good. Conclusion: In HBV hyperendemic areas, occult hepatitis B transfusion might not lead to HBsAg carriage or PTH. The risk of transfusion-transmitted HBV infection was probably lower than that in non-endemic areas because most recipients had already experienced HBV infection. ? 2010 The Authors. Transfusion Medicine ? 2010 British Blood Transfusion Society.
|ISSN:||0958-7578||DOI:||10.1111/j.1365-3148.2010.01036.x||SDG/Keyword:||hepatitis B surface antigen; virus DNA; adult; article; blood donor; blood transfusion; clinical article; controlled study; female; follow up; gene sequence; hepatitis B; Hepatitis B virus; human; male; nonhuman; polymerase chain reaction; posttransfusion hepatitis; serology; Taiwan; virus transmission
|Appears in Collections:||醫學系|
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