https://scholars.lib.ntu.edu.tw/handle/123456789/551332
標題: | A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women | 作者: | Lien, Guang-Wen WU-SHIUN HSIEH WEN-HUNG KUO CHING-HUA KUO Huang, Ching-Chun YUE-LIANG GUO DWANG-YING CHANG YEN-SHEN LU CHIUN-SHENG HUANG ANN-LII CHENG CHING-HUNG LIN PAU-CHUNG CHEN |
公開日期: | 2020 | 出版社: | Elsevier Ltd | 卷: | 142 | 來源出版物: | Environment International | 摘要: | Breast cancer (BC) is a common cancer in women worldwide; however, the incidence of BC is increasing in younger women, possibly associated with the environment. Perfluoroalkyl substances (PFAS) are one of endocrine disruptors that accumulate in environment and impact human health. This study aimed to investigate whether the PFAS and BC are associated. We enrolled 120 BCE patients and 119 controls at National Taiwan University Hospital (NTUH) and also collected bio-specimen and questionnaire from 2013 to 2015. All subjects’ plasma PFAS levels were analyzed by ultra-performance liquid chromatography tandem mass spectrometry method with electrospray ionization (UHPLC-ESI-MS/MS). A logistic regression model was used to estimate the association between PFAS and BC. In the ?50 years age group, the adjusted odds ratio (OR) was 2.34 (95% CI = 1.02, 5.38) for perfluorooctane sulfonate (PFOS) exposure per natural log unit increase. After stratifying the estrogen receptor (ER) status and age group, we obtained a positive association for PFHxS and PFOS concentrations with respect to the risk of ER positive tumors for ?50 years age group. In conclusion, we found that PFAS were associated with the BC risk of ER positive tumors in young Taiwanese women. Further studies are needed to follow and explore whether these associations are causal. ? 2020 The Author(s) |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086652193&doi=10.1016%2fj.envint.2020.105850&partnerID=40&md5=d66e912c55ed55a154c4b3c4534e0ab2 https://scholars.lib.ntu.edu.tw/handle/123456789/551332 |
ISSN: | 0160-4120 | DOI: | 10.1016/j.envint.2020.105850 | SDG/關鍵字: | Drug products; Electrospray ionization; Liquid chromatography; Logistic regression; Mass spectrometry; Tumors; Case-control study; Endocrine disruptor; Estrogen receptor; Logistic Regression modeling; National Taiwan University; Perfluoroalkyl substances; Perfluorooctane sulfonates; Ultra performance liquid chromatography; Diseases; endocrine disruptor; estrogen receptor; perfluoroalkyl substance; perfluorooctanesulfonic acid; unclassified drug; alkanesulfonic acid; fluorocarbon; octanoic acid derivative; bioaccumulation; cancer; chromatography; endocrine disruptor; health impact; health risk; ionization; mass spectrometry; womens health; adult; age distribution; Article; blood level; breast cancer; cancer incidence; cancer risk; case control study; clinical feature; concentration (parameter); controlled study; cross-sectional study; disease association; electrospray; environmental exposure; ethnicity; female; human; liquid chromatography-mass spectrometry; major clinical study; priority journal; Taiwanese; ultra performance liquid chromatography; university hospital; breast tumor; pollutant; Taiwan; tandem mass spectrometry; toxicity; Taiwan; Alkanesulfonic Acids; Breast Neoplasms; Caprylates; Case-Control Studies; Environmental Pollutants; Female; Fluorocarbons; Humans; Taiwan; Tandem Mass Spectrometry; Women |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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