https://scholars.lib.ntu.edu.tw/handle/123456789/551343
標題: | Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively | 作者: | Kuo C.-H. Wei J.-N. Yang C.-Y. Ou H.-Y. Wu H.-T. KANG-CHIH FAN SHU-HUEI WANG Hua C.-H. Hsiao C.-H. Lee M.-K. HUNG-YUAN LI |
公開日期: | 2019 | 出版社: | Nature Publishing Group | 卷: | 43 | 期: | 3 | 起(迄)頁: | 512-522 | 來源出版物: | International Journal of Obesity | 摘要: | Background/objectives: Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods: From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ? 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ? 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ? 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results: sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p < 0.001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = ?0.1449, p = 0.003), waist circumference (r = ?0.1425, p = 0.004), abdominal visceral (r = ?0.1457, p = 0.003), and subcutaneous (r = ?0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = ?0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 ± 2.6 years, 73 subjects (12.2%) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-%B and HOMA2-IR (HR = 0.66, 95% CI = 0.50–0.88, p < 0.01). Conclusions: sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human. ? 2018, Springer Nature Limited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050134500&doi=10.1038%2fs41366-018-0172-4&partnerID=40&md5=43bb7e3cd2be263657bb27902c01e0d0 https://scholars.lib.ntu.edu.tw/handle/123456789/551343 |
ISSN: | 0307-0565 | DOI: | 10.1038/s41366-018-0172-4 | SDG/關鍵字: | adiponectin; C reactive protein; vascular adhesion protein 1; adiponectin; ADIPOQ protein, human; amine oxidase (copper containing); AOC3 protein, human; C reactive protein; cell adhesion molecule; abdominal fat; adult; Article; body mass; cohort analysis; controlled study; enzyme linked immunosorbent assay; family history; fasting; female; glucose blood level; glucose transport; human; hyperglycemia; impaired glucose tolerance; intra-abdominal fat; major clinical study; male; middle aged; oral glucose tolerance test; priority journal; protein blood level; retrospective study; subcutaneous fat; upregulation; waist circumference; blood; hyperglycemia; impaired glucose tolerance; longitudinal study; metabolism; non insulin dependent diabetes mellitus; obesity; Taiwan; upregulation; Adiponectin; Adult; Amine Oxidase (Copper-Containing); C-Reactive Protein; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Longitudinal Studies; Male; Middle Aged; Obesity; Prediabetic State; Taiwan; Up-Regulation |
顯示於: | 醫學系 |
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