https://scholars.lib.ntu.edu.tw/handle/123456789/551479
標題: | Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women | 作者: | Kung A.W.-C. Rachman I.A. Adam J.M.F. Roeshadi D. Torralba T. Navarra S. Gamilla Z. Ca?ete A. de la Rosa M. KEH-SUNG TSAI Lin H.-Y. Soong Y.K. Lan J.-L. Hsu H.-C. Tu S.-T. Lin R.-M. Yuktanandana P. Songpatanasilp T. Ngarmukos S. Soontrapa S. Soontrapa S. Rojanasthien S. Luevitoonvechkij S. Leerapan T. Albert A. Vanbelle S. |
關鍵字: | Adherence; Bone marker; Compliance; Feedback; Ibandronate; Osteoporosis | 公開日期: | 2009 | 卷: | 12 | 期: | 3 | 起(迄)頁: | 216-224 | 來源出版物: | International Journal of Rheumatic Diseases | 摘要: | Aim: his study assesses the impact of serum carboxy-terminal collagen crosslinks (CTX) bone marker feedback (BMF) on adherence to ibandronate treatment in Asian postmenopausal women with osteoporosis. Methods: This was a 12-month (6-monthly phased), randomized, prospective, open-label, multi-center study conducted in 596 (of 628 enrolled) postmenopausal women with osteoporosis (? 85 years old) who were na?ve, lapsed, or current bisphosphonate users. Patients were randomized into two arms: serum CTX BMF at 3 months versus no-BMF. Once-monthly 150 mg ibandronate tablet was administered for 12 months and adherence to therapy was assessed at 6 and 12 months. In addition, patient satisfaction and safety of ibandronate treatment were also assessed. Results: Serum CTX BMF at 3 months showed no impact on adherence. The proportions of adherent patients were comparable in the BMF versus no-BMF arms (92.6% vs. 96.0%, P = 0.16); overall, serum CTX levels were similar for adherent and non-adherent patients. However, BMF patients felt more informed about their osteoporosis (P < 0.001) and more satisfied (P < 0.01) than no-BMF patients. Conclusions: The Asian postmenopausal osteoporosis patients in this study had a high adherence rate to once-monthly ibandronate therapy. Use of serum CTX BMF had no further impact on increasing adherence, but increased treatment satisfaction. ? 2009 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551479 | ISSN: | 1756-1841 | DOI: | 10.1111/j.1756-185X.2009.01413.x | SDG/關鍵字: | bisphosphonic acid derivative; carboxy terminal telopeptide; ibandronic acid; aged; article; Asian; blood sampling; cardiovascular disease; clinical trial; comparative study; connective tissue disease; controlled clinical trial; controlled study; drug safety; female; gastrointestinal disease; hematologic disease; human; ileus; infection; major clinical study; metabolic disorder; multicenter study; musculoskeletal disease; neurologic disease; open study; patient compliance; patient education; patient information; patient satisfaction; postmenopause; postmenopause osteoporosis; priority journal; protein blood level; psychopathy; randomized controlled trial; Administration, Oral; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Biological Markers; Bone and Bones; Bone Density Conservation Agents; Diphosphonates; Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Patient Compliance; Patient Satisfaction |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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