https://scholars.lib.ntu.edu.tw/handle/123456789/551512
標題: | The hypoglycemic effects of soy isoflavones on postmenopausal women | 作者: | SHAO-YI CHENG Shaw N.-S. KEH-SUNG TSAI CHING-YU CHEN |
公開日期: | 2004 | 卷: | 13 | 期: | 10 | 起(迄)頁: | 1080-1086 | 來源出版物: | Journal of Women's Health | 摘要: | Objectives: Soy isoflavones have many effects similar to those of estrogen and have become popular among postmenopausal women as an alternative for hormone replacement therapy (HRT). The purpose of this study was to determine the effects of soy isoflavones on glucose, insulin, and lipid profiles in postmenopausal Taiwanese women. Methods: We conducted a randomized, double-blind, active placebo-controlled clinical trial to compare the effects of isoflavones with estrogen replacement therapy (ERT) on blood glucose, insulin, and lipid profiles in postmenopausal Taiwanese women. Thirty postmenopausal Taiwanese women were randomly assigned to two groups, and each received treatment for 6 months. The isoflavone group received 100 mg isoflavone soft capsules, 300 mg calcium, and a blank vitamin capsule per day. The estrogen active control group received 0.625 mg conjugated estrogen, 300 mg calcium, and blank isoflavone soft capsules per day. We measured baseline levels of fasting blood sugar, insulin, lipid profiles, and isoflavone concentrations prior to the study and repeated the same measurements every 3 months for a total duration of 6 months. Results: Two-way ANOVA revealed that fasting glucose (p < 0.001) and insulin (p < 0.005) levels were significantly affected by estrogen and isoflavone treatments after 6 months. For the isoflavone group, the average blood genistein concentration was 6-10 times higher than those of the estrogen group. Within the same periods, the fasting blood glucose was reduced to 83% and 85% of the baseline levels, and insulin was reduced to 56% and 67% of the baseline levels, respectively, in the estrogen and isoflavone groups. Conclusions: Soy isoflavones (100 mg) and 0.625 mg conjugated estrogen equally lower fasting blood glucose and insulin levels in postmenopausal women. ? Mary Ann Liebert, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551512 | ISSN: | 1540-9996 | DOI: | 10.1089/jwh.2004.13.1080 | SDG/關鍵字: | calcium; conjugated estrogen; daidzein; genistein; glucose; insulin; isoflavone derivative; lipid; placebo; primrose oil; vitamin; adult; aged; analysis of variance; article; clinical article; clinical trial; controlled clinical trial; controlled study; double blind procedure; drug blood level; drug capsule; drug dose regimen; drug efficacy; estrogen therapy; female; glucose blood level; human; insulin blood level; insulin sensitivity; lipid blood level; menopausal syndrome; non insulin dependent diabetes mellitus; priority journal; randomized controlled trial; statistical significance; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。