https://scholars.lib.ntu.edu.tw/handle/123456789/551748
標題: | Temporal changes in cardiac force- and flow-generation capacity, loading conditions, and mechanical efficiency in streptozotocin-induced diabetic rats | 作者: | Yeih D.-F. LIAN-YU LIN Yeh H.-I. Lai Y.-J. FU-TIEN CHIANG Tseng C.-D. Chu S.-H. Tseng Y.-Z. |
公開日期: | 2008 | 卷: | 294 | 期: | 2 | 起(迄)頁: | H867-H874 | 來源出版物: | American Journal of Physiology - Heart and Circulatory Physiology | 摘要: | Diabetes mellitus may result in impaired cardiac contractility, but the underlying mechanisms remain unclear. We aimed to investigate the temporal alterations in cardiac force- and flow-generation capacity and loading conditions as well as mechanical efficiency in the evolution of systolic dysfunction in streptozotocin (STZ)-induced diabetic rats. Adult male Wistar rats were randomized into control and STZ-induced diabetic groups. Invasive hemodynamic studies were done at 8, 16, and 22 wk post-STZ injection. Maximal systolic elastance (Emax) and maximum theoretical flow (Q max) were assessed by curve-fitting techniques, and ventriculoarterial coupling and mechanical efficiency were assessed by a single-beat estimation technique. In contrast to early occurring and persistently depressed Emax, Qmax progressively increased with time but was decreased at 22 wk post-STZ injection, which temporally correlated with the changes in cardiac output. The favorable loading conditions enhanced stroke volume and Qmax, whereas ventriculoarterial uncoupling attenuated the cardiac mechanical efficiency in diabetic animals. The changes in Emax and Qmax are discordant during the progression of contractile dysfunction in the diabetic heart. In conclusion, our study showed that depressed Qmax and cardiac mechanical efficiency, occurring preceding overt systolic heart failure, are two major determinants of deteriorating cardiac performance in diabetic rats. Copyright ? 2008 the American Physiological Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551748 | ISSN: | 0363-6135 | DOI: | 10.1152/ajpheart.00573.2007 | SDG/關鍵字: | streptozocin; animal experiment; animal model; article; controlled study; curve fitting; deterioration; diabetes mellitus; heart muscle compliance; heart muscle contractile force; heart muscle contractility; heart output; heart performance; heart stroke volume; hemodynamics; male; nonhuman; priority journal; rat; streptozocin diabetes; systolic dysfunction; systolic heart failure; Algorithms; Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiac Output; Diabetes Mellitus, Experimental; Elasticity; Heart; Male; Myocardial Contraction; Myocardium; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Stroke Volume; Vascular Resistance; Ventricular Function, Left |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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