https://scholars.lib.ntu.edu.tw/handle/123456789/551784
標題: | Molecular genetic study of hypertension | 作者: | Chern T.-H. FU-TIEN CHIANG |
關鍵字: | Association analysis; Candidate genes; Genetic markers; Genetics; Hypertension; Linkage analysis | 公開日期: | 2004 | 卷: | 20 | 期: | 3 | 起(迄)頁: | 129-138 | 來源出版物: | Acta Cardiologica Sinica | 摘要: | Hypertension is a rising problem in the developed countries. Some rare familial hypertensive syndromes have been found to be caused by monogenic mutations. Essential hypertension is generally regarded as a complex genetic trait caused by multiple genes. The polygenic effects on blood pressure are modulated by gene-gene and gene-environment interactions. Most investigations for genetic causes of essential hypertension were approached with candidate genes, and a few candidate genes, such as angiotensinogen gene, were reported to be associated with essential hypertension, though the reports from different populations were still conflicting. Genome-wide scans with multiple markers have mapped several loci associated with blood pressure. The loci reported were on chromosomes 2p, 2q, 5q, 6q, 15q, 17, and 18q respectively. However, to date, no genotype had been conclusively linked to essential hypertension. It has long been hoped that genetic research on hypertensive animals, such as rats, will facilitate our understanding of the genetics of human essential hypertension. So far, more than twenty loci were reported to be associated with blood pressure in rats. More understanding of the genetic basis of essential hypertension should be possible in the future and would be expected to help earlier diagnosis, more effective risk factor assessment and more individualized treatment of hypertension. However, the difficulty of genetic analysis for essential hypertension and the possibility of inter-population differences in genetic factors should be kept in mind. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551784 | ISSN: | 1011-6842 | SDG/關鍵字: | 11beta hydroxysteroid dehydrogenase; adducin; alpha adrenergic receptor; angiotensin 1 receptor; angiotensinogen; atrial natriuretic factor; beta adrenergic receptor; dipeptidyl carboxypeptidase; endothelial nitric oxide synthase; sodium channel; animal model; blood pressure; candidate gene; chromosome 15q; chromosome 17; chromosome 18q; chromosome 2p; chromosome 2q; chromosome 5q; chromosome 6q; disease association; essential hypertension; familial disease; gene; gene locus; gene mapping; gene mutation; genetic linkage; genome; human; hyperaldosteronism; hypertension; Liddle syndrome; missense mutation; nonhuman; phenotype; quantitative trait locus; renin angiotensin aldosterone system; review |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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