|Title:||24-Hour Ambulatory Blood Pressure Variability in Children with Obstructive Sleep Apnea||Authors:||Kang, Kun Tai
Hsu, Wei Chung
|Keywords:||Ambulatory blood pressure monitoring | blood pressure | child | polysomnography | sleep apnea syndromes;Ambulatory blood pressure monitoring; blood pressure; child; polysomnography; sleep apnea syndromes||Issue Date:||1-Jan-2021||Source:||Laryngoscope||Abstract:||
© 2021 The American Laryngological, Rhinological and Otological Society, Inc. Objective: To evaluate blood pressure (BP) variability in 24-hour ambulatory BP monitoring in children with obstructive sleep apnea (OSA). Study Design: Case series study. Methods: Children aged 4 to 16 years with clinical symptoms were recruited in a tertiary medical center. Overnight polysomnography and 24-hour recordings of ambulatory BP were performed for each child. The severity of OSA was classified as primary snoring (apnea-hypopnea index [AHI] < 1), mild OSA (1 ≤ AHI < 5), moderate OSA (10 > AHI ≥ 5), and severe OSA (AHI ≥ 10). The standard deviation of mean BP was used as an indicator of BP variability. Results: A total of 550 children were included (mean age: 7.6 years; 70% were boys; 20% were obese). Compared with the children with primary snoring, children with severe OSA exhibited significantly higher nighttime systolic BP (108.0 vs. 100.5 mmHg, P <.001), nighttime diastolic BP (58.9 vs 55.6 mmHg, P =.002), nighttime mean arterial pressure (75.3 vs. 70.5 mmHg, P <.001), nighttime systolic BP load (40.5% vs. 25.0%, P <.001), nighttime diastolic BP load (25.3% vs. 12.9%, P <.001), and nighttime systolic BP variability (11.4 vs. 9.6, P =.001). Multiple linear regression analyses revealed an independent association between AHI and nighttime systolic BP variability (regression coefficient = 0.31, 95% CI = 0.06–0.56, P =.015) after adjustment for age, gender, adiposity, and hypertensive status. Conclusions: OSA in children is associated with increased BP and BP variability. Level of Evidence: 4 Laryngoscope, 2021.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/552560||ISSN:||0023852X||DOI:||10.1002/lary.29455||metadata.dc.subject.other:||adolescent; apnea hypopnea index; arousal index; Article; blood pressure monitoring; blood pressure variability; body mass; child; childhood obesity; circadian rhythm; diastolic blood pressure; disease severity; female; human; hypertension; major clinical
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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