https://scholars.lib.ntu.edu.tw/handle/123456789/552722
標題: | Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population | 作者: | Yeh T.-K. CHUNG-YI HU Yeh T.-C. Lin P.-J. Wu C.-H. Lee P.-L. Chang C.-Y. |
公開日期: | 2012 | 卷: | 80 | 期: | 2 | 起(迄)頁: | 282-289 | 來源出版物: | Brain and Cognition | 摘要: | The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged. ? 2012 Elsevier Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/552722 | ISSN: | 0278-2626 | DOI: | 10.1016/j.bandc.2012.06.005 | SDG/關鍵字: | 5,10 methylenetetrahydrofolate reductase (FADH2); brain derived neurotrophic factor; dopamine 3 receptor; adult; article; auditory memory; brain derived neurotrophic factor gene; Chinese; cognition; controlled study; dopaminergic system; female; gene; genetic association; human; long term memory; male; memory; mental performance; methylenetetrahydrofolate reductase gene; normal human; priority journal; single nucleotide polymorphism; Taiwan; Wechsler Intelligence Scale; Wechsler Memory Scale; Acoustic Stimulation; Adolescent; Asian Continental Ancestry Group; Brain-Derived Neurotrophic Factor; Cognition; Female; Gene Frequency; Genetic Association Studies; Humans; Male; Memory; Methylenetetrahydrofolate Reductase (NADPH2); Neuropsychological Tests; Polymorphism, Single Nucleotide; Receptors, Dopamine D3; Taiwan; Young Adult |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。