https://scholars.lib.ntu.edu.tw/handle/123456789/552745
標題: | Familial transmission of human T-lymphocyte virus type (HTLV-1) in patients with adult T-cell leukemia/lymphoma or HTLV-1-associated myelopathy | 作者: | CHUNG-YI HU Lin M.-T. YA-CHIEN YANG JIH-LUH TANG LI-HUI TSENG Wang C.-H. YAO-CHANG CHEN Yang C.-S. |
公開日期: | 1998 | 卷: | 97 | 期: | 2 | 起(迄)頁: | 101-105 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | The seroprevalence of human T-lymphotropic virus type 1 (HTLV-1) in Taiwan is 0.48%. In this study, we investigated the patterns of intrafamilial transmission of HTLV-1 in Taiwanese patients with adult T-cell leukemia/lymphoma ATL/L) or tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/ HAM). Fifteen index patients (9 men, 6 women, aged 31-71 yr), 13 with ATL/L, and two with TSP/HAM, and 98 relatives were included. Of the 98 relatives, 23 were seropositive for HTLV-1. Spouses of 11 patients were studied. Seven of eight wives of male patients but none of the three husbands of female patients were HTLV-1 carriers. Mother-to-child transmission was found in seven of 13 families and in 15 of 75 children tested. The correlation of breast-feeding with seropositivity in two families with seropositive mothers indicates its important role in vertical transmission of HTLV-1. Our findings suggest that husband-to-wife and mother-to-child transmission are the main forms of intrafamilial transmission of HTLV-1 in Taiwan, a nonendemic area. Screening for HTLV-1 in family members of patients with ATL/L or TSP/HAM, and seropositive blood donors, may be warranted. Seropositive individuals should be educated to prevent the spread of the virus through sexual contact and breast feeding. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/552745 | ISSN: | 0929-6646 | SDG/關鍵字: | adult; aged; article; blood donor; clinical article; controlled study; family; family study; female; human; human t cell leukemia virus 1; male; mass screening; mother; relative; screening; seroprevalence; spinal cord disease; spouse; t cell leukemia; t cell lymphoma; vertical transmission; virus transmission; virus typing; Adult; Aged; Breast Feeding; Family; Female; Humans; Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated; Male; Middle Aged; Paraparesis, Tropical Spastic; Sexual Behavior |
顯示於: | 醫學檢驗暨生物技術學系 |
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