https://scholars.lib.ntu.edu.tw/handle/123456789/553197
標題: | High expression of stathmin protein predicts a fulminant course in medulloblastoma: Clinical article | 作者: | MENG-FAI KUO Wang, Huei-Shyong Kuo, Quang-Ting CHIA-TUNG SHUN Hsu, Hey-Chi SHIH-HUNG YANG RAY-HWANG YUAN |
公開日期: | 2009 | 卷: | 4 | 期: | 1 | 起(迄)頁: | 74-80 | 來源出版物: | Journal of Neurosurgery: Pediatrics | 摘要: | Object. Stathmin, an important cytosolic phosphoprotein, is involved in cell proliferation and motility. This study was performed to elucidate the role of stathmin in the progression of medulloblastoma. Methods. The expression of stathmin protein was examined by immunohistochemical staining of tumor sections obtained in 17 consecutive patients with medulloblastoma who underwent resection between 1995 and 2005. Four patients were excluded because they were either lost to follow-up or underwent biopsy sampling only, leaving a total of 13 patients in the study. The stathmin expression was scored according to the immunoreactive fraction of tumor cells, and the level was correlated with various clinicopathological factors. Results. The expression level of stathmin protein was ? 10% in 9 patients, 11-50% in 1, and > 50% in 3. No staining was seen in the tissues adjacent to the tumors. For comparison, the authors grouped the expression level of stathmin into high (> 50%) and low (? 50%). It was found that patients with high expression of stathmin had more frequent tumor dissemination at the time of resection or soon after total excision of the tumor (p = 0.0035), and hence experienced a fulminant course with lower patient survival (p < 0.0001), with an average survival period of 6.7 months (range 2-10 months). The expression level of stathmin did not correlate with patient age, sex, CSF cytological findings, use of adjuvant therapies, Ki 67 index, or risk classification of the tumors according to previously described categories in the literature. Conclusions. High stathmin expression correlates with tumor dissemination, is an important prognostic factor of medulloblastoma, and may serve as a useful marker for more intensive adjuvant therapies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/553197 | ISSN: | 1933-0707 | DOI: | 10.3171/2009.2.PEDS08287 | SDG/關鍵字: | Ki 67 antigen; stathmin; adolescent; adult; article; cancer surgery; cancer survival; cerebrospinal fluid cytology; child; clinical article; controlled study; female; follow up; human; human tissue; immunohistochemistry; male; medulloblastoma; metastasis; preschool child; priority journal; prognosis; protein expression; school child; tumor biopsy; tumor cell; tumor growth; Age Factors; Cerebellar Neoplasms; Child; Child, Preschool; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Medulloblastoma; Prognosis; Sex Factors; Stathmin; Up-Regulation |
顯示於: | 法醫學科所 |
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