https://scholars.lib.ntu.edu.tw/handle/123456789/553259
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee J.-E. | en_US |
dc.contributor.author | CHIA-TUNG SHUN | en_US |
dc.contributor.author | SONG-CHOU HSIEH | en_US |
dc.contributor.author | SUNG-TSANG HSIEH | en_US |
dc.creator | Lee J.-E.;Chia-Tung Shun;Hsieh S.-C.;Hsieh S.-T. | - |
dc.date.accessioned | 2021-03-18T02:03:17Z | - |
dc.date.available | 2021-03-18T02:03:17Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0003-9942 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/553259 | - |
dc.description.abstract | Background: Skin denervation in vasculitic neuropathy has rarely been documented despite frequent manifestations of small-fiber neuropathy including reduced sensitivity and neuropathic pain. Recently, skin biopsy has been established as a new approach to diagnose small-fiber sensory neuropathy. Objectives: To investigate the pathologic features of cutaneous nerves and to evaluate inflammatory vasculopathy in the skin of patients with vasculitis. Design: Case series. Setting: National Taiwan University Hospital, Taipei. Patients: Six patients with vasculitic neuropathy. Interventions: Patients had 3-mm punch biopsy specimens taken from the distal part of the leg (without active vasculitic lesions) and a sural nerve biopsy specimen was taken in addition to detailed neurologic examinations, laboratory investigations, and nerve conduction studies. Main Outcome Measures: Results of nerve conduction studies, epidermal nerve fiber density studies, and immunohistochemistry. Results: All 6 patients had combined large-and small-nervef iber involvement on the neurologic examinations. Nerve conduction studies showed a pattern of axonal neuropathy or mononeuropathy multiplex. Epidermal nerve fiber densities were significantly reduced in the skin of all patients, consistent with concomitant small-fiber neuropathies. Perivascular infiltration by T cells and macrophages was demonstrated by immunohistochemistry. All patients experienced neurologic improvement in muscle strength and alleviation of sensory symptoms after immunotherapy with corticosteroids, plasma exchange, or cyclophosphamide. Conclusions: Small-diameter sensory nerves are affected in vasculitis in addition to the well-known effect of vasculitis on large-diameter nerves. Significant inflammatory vasculopathy is present in the skin despite the absence of clinically active vasculitic lesions. ? 2005 American Medical Association. All rights reserved. | - |
dc.relation.ispartof | Archives of Neurology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | corticosteroid; cyclophosphamide; adult; article; cell infiltration; clinical article; clinical feature; denervation; density; female; human; immunohistochemistry; immunotherapy; inflammation; laboratory; macrophage; male; muscle strength; nerve biopsy; nerve conduction; nerve fiber; neurologic examination; neuropathy; pathology; plasmapheresis; priority journal; punch biopsy; sensory nerve; skin; skin nerve; sural nerve; T lymphocyte; vascular disease; vasculitis; Adolescent; Denervation; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neural Conduction; Peripheral Nervous System Diseases; Skin; Sural Nerve; Vasculitis | - |
dc.title | Skin denervation in vasculitic neuropathy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1001/archneur.62.10.1570 | - |
dc.identifier.pmid | 16216940 | - |
dc.identifier.scopus | 2-s2.0-26444544500 | - |
dc.relation.pages | 1570-1573 | - |
dc.relation.journalvolume | 62 | - |
dc.relation.journalissue | 10 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.orcid | 0000-0002-0468-4468 | - |
crisitem.author.orcid | 0000-0002-3188-8482 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 法醫學科所 |
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