https://scholars.lib.ntu.edu.tw/handle/123456789/553285
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HAN-MO CHIU | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | CHIA-TUNG SHUN | en_US |
dc.contributor.author | Lin J.-T. | en_US |
dc.creator | Chiu H.-M.;Wu M.-S.;Hung C.-C.;Chia-Tung Shun;Lin J.-T. | - |
dc.date.accessioned | 2021-03-18T02:03:24Z | - |
dc.date.available | 2021-03-18T02:03:24Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/553285 | - |
dc.description.abstract | Background and Aims: The role of Helicobacter pylori infection in gastroduodenal lesions might be different between the general population and AIDS patients. The aim of the present study was to compare the prevalence of H. pylori and cytomegalovirus (CMV) infection in AIDS patients and HIV-negative controls. The impact of CD4 lymphocyte counts on H. pylori and CMV infection in the same subjects was also assessed. Methods: One hundred and fifty-six patients (52 HIV-positive, 104 HIV-negative) with gastrointestinal symptoms were evaluated with upper gastrointestinal endoscopy and biopsy. Comparison of the prevalence of H. pylori and CMV infection was made by dividing AIDS patients into two groups: those with CD4 counts >100/mm3 and those with CD4 counts <100/mm3, and ulcer and non-ulcer patients. Results: In comparison with HIV-negative controls, AIDS patients had a lower prevalence of H. pylori infection (P < 0.0001) but a higher prevalence of CMV infection (P < 0.0001). Cytomegalovirus infection was frequently found in AIDS patients with CD4 count <100/mm3, in comparison with those with a CD4 count >100/mm3. In AIDS patients, CMV was more frequently detected in subjects with peptic ulcers (P = 0.0125). Conversely, the prevalence of H. pylori infection in AIDS patients was not different between those with and without peptic ulcers. Conclusions: The low prevalence of H. pylori infection and peptic ulcer in AIDS patients suggests a different role of H. pylori infection in peptic ulcer or even a different mechanism of peptic ulcerogenesis in HIV-positive subjects. Cytomegalovirus, rather than H. pylori, may be the main causative pathogen of peptic ulcers in AIDS patients. ? 2004 Blackwell Publishing Asia Pty Ltd. | - |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology (Australia) | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD4 antigen; acquired immune deficiency syndrome; adult; aged; article; comparative study; controlled study; Cytomegalovirus; cytomegalovirus infection; disease association; endoscopy; female; gastrointestinal biopsy; gastrointestinal endoscopy; gastrointestinal symptom; Helicobacter infection; Helicobacter pylori; human; Human immunodeficiency virus; lymphocyte count; major clinical study; male; medical assessment; patient; peptic ulcer; prevalence; priority journal; symptom; upper gastrointestinal tract | - |
dc.title | Low prevalence of Helicobacter pylori but high prevalence of cytomegalovirus-associated peptic ulcer disease in AIDS patients: Comparative study of symptomatic subjects evaluated by endoscopy and CD4 counts | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1440-1746.2003.03278.x | - |
dc.identifier.scopus | 2-s2.0-2342465449 | - |
dc.relation.pages | 423-428 | - |
dc.relation.journalvolume | 19 | - |
dc.relation.journalissue | 4 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.orcid | 0000-0003-2786-8056 | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0002-0468-4468 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 法醫學科所 |
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