https://scholars.lib.ntu.edu.tw/handle/123456789/553361
標題: | Relationship of p53 and c-erbB-2 expression to histopathological features, Helicobacter pylori infection and prognosis in gastric cancer | 作者: | CHIA-TUNG SHUN MING-SHIANG WU Lin J.-T. Chen S.-Y. HSIU-PO WANG Lee W.-J. Wang T.-H. Chuang S.-M. |
公開日期: | 1997 | 卷: | 44 | 期: | 14 | 起(迄)頁: | 604-609 | 來源出版物: | Hepato-Gastroenterology | 摘要: | Background/Aims: Conflicting results concerning the relationships between abnormal expression of p53 and c-erbB-2 and biologic behavior of gastric cancer are noted. Therefore, overexpression of p53 and c-erbB-2 in relation to the following aspects of gastric cancer: tumor histopathology, Helicobacter pylori infection, and prognosis are explored. Materials and Method: Expression of p53 and c-erbB-2 by immunohistochemistry was correlated with histopathology, H. pylori infection and prognosis of gastric cancer in 112 patients. Results: Positive p53 staining was found in 61 (54.5%) of 112 tumors examined. There was no association of p53 expression with sex, age, lymph node metastasis, H. pylori infection or prognosis. A significantly higher frequency of p53-positive staining was observed in advanced (60.7%), intestinal (69.8%) and cardia (76.5%) than in early (30.4%, p < 0.01), diffuse (34.7%, p < 0.01) and noncardia (50.5%, p < 0.05) carcinoma, respectively. Expression of c-erbB-2 was found in 34 cases (30.3%), and was not related to sex, age, H. pylori infection and tumor location. Tumors with positive c-erbB-2 staining appeared to behave more aggressively in view of higher rates of nodal metastasis (38.0% vs 17.1%, p < 0.05), advanced stage (37.1% vs 4.3%, p < 0.01) and poor mean survival (p < 0.01). Patients with intestinal type tumors also had a significantly higher rate of c-erbB-2 expression than those with diffuse tumors (39.7% vs 18.4%, p < 0.01). Conclusions: Our results indicate that immunohistochemical expressions of p53 and c-erbB-2 are significantly associated with some histopathological phenotypes. Genetic alterations of c-erbB-2 or p53 may not be affected by H. pylori infection. C-erbB-2 expression may be used as a marker for identifying more aggressive gastric cancer for designing further therapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/553361 | ISSN: | 0172-6390 | SDG/關鍵字: | marker; adult; aged; article; cancer survival; early cancer; female; gene expression; gram negative infection; helicobacter pylori; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; metastasis; oncogene c erb; phenotype; priority journal; prognosis; staining; stomach cancer; tumor suppressor gene; Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Carcinoma; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, p53; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Phenotype; Prognosis; Receptor, erbB-2; Sex Factors; Stomach Neoplasms; Survival Rate; Tumor Markers, Biological; Tumor Suppressor Protein p53 |
顯示於: | 法醫學科所 |
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