https://scholars.lib.ntu.edu.tw/handle/123456789/554464
標題: | Clinical characteristics and long-term evolution of lamellar macular hole in high myopia | 作者: | Hsia Y. TZYY-CHANG HO CHANG-HAO YANG YI-TING HSIEH TSO-TING LAI CHUNG-MAY YANG |
公開日期: | 2020 | 出版社: | Public Library of Science | 卷: | 15 | 期: | 5 | 起(迄)頁: | e0232852 | 來源出版物: | PLoS ONE | 摘要: | Purpose To evaluate the clinical characteristics and evolution of lamellar macular hole (LMH) in high myopia and the parameters associated with structural worsening, defined as the development of foveal detachment or full-thickness macular hole. Methods Patients with high myopia and LMH were retrospectively recruited. The clinical characteristics and various parameters of optical coherence tomography were identified at baseline and during follow-up visits. Cox regression analysis was used to evaluate the hazard ratios for foveal detachment and full-thickness macular hole. Results Among 112 eyes (98 patients), 64.3% were female; the mean axial length of all eyes was 29.6 ± 1.9 mm. The ‘LMH without retinoschisis’ group accounted for 39.3% of the eyes. Forty-two percent developed structural worsening within a median follow-up of 67 months. Multivariable regression on all cases showed elevated tissue inside the LMH (P = 0.003) protected against structural worsening while V-shaped LMH (P = 0.006) predicted it. In the “LMH with retinoschisis group”, ellipsoid zone disruption (P = 0.035), and V-shaped LMH (P = 0.014) predicted structural worsening, while elevated tissue inside the LMH (P = 0.028) protected against it. In the “LMH without retinoschisis group”, no associated factor was identified. Conclusions LMHs in high myopia are unstable, especially those with V-shaped LMH. Elevated tissue inside LMHs have a protective effect against further structural worsening. ? 2020 Hsia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084322741&doi=10.1371%2fjournal.pone.0232852&partnerID=40&md5=3a08c912f6287046b797e246bd7dde6c https://scholars.lib.ntu.edu.tw/handle/123456789/554464 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0232852 | SDG/關鍵字: | adult; Article; clinical decision making; controlled study; disease course; eye axis length; female; follow up; high myopia; human; human tissue; major clinical study; male; middle aged; optical coherence tomography; prediction; retina detachment; retina macula hole; retina tissue; retinal thickness; retinoschisis; retrospective study; risk factor; vitrectomy; aged; complication; degenerative myopia; disease exacerbation; epiretinal membrane; pathophysiology; proportional hazards model; retina detachment; retina fovea; retina tear; ultrastructure; visual acuity; Aged; Disease Progression; Epiretinal Membrane; Female; Follow-Up Studies; Fovea Centralis; Humans; Male; Middle Aged; Myopia, Degenerative; Proportional Hazards Models; Retinal Detachment; Retinal Perforations; Retrospective Studies; Tomography, Optical Coherence; Visual Acuity |
顯示於: | 醫學系 |
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