https://scholars.lib.ntu.edu.tw/handle/123456789/554479
Title: | Time to peak and full width at half maximum in MR perfusion: valuable indicators for monitoring moyamoya patients after revascularization | Authors: | Huang, Adam CHUNG-WEI LEE HON-MAN LIU |
Issue Date: | 12-Jan-2021 | Journal Volume: | 11 | Journal Issue: | 1 | Source: | Scientific reports | Abstract: | Moyamoya disease (MMD) is a chronic, steno-occlusive cerebrovascular disorder of unknown etiology. Surgical treatment is the only known effective method to restore blood flow to affected areas of the brain. However, there are lack of generally accepted noninvasive tools for therapeutic outcome monitoring. As dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) is the standard MR perfusion imaging technique in the clinical setting, we investigated a dataset of nineteen pediatric MMD patients with one preoperational and multiple periodic DSC MRI examinations for four to thirty-eight months after indirect revascularization. A rigid gamma variate model was used to derive two nondeconvolution-based perfusion parameters: time to peak (TTP) and full width at half maximum (FWHM) for monitoring transitional bolus delay and dispersion changes respectively. TTP and FWHM values were normalized to the cerebellum. Here, we report that 74% (14/19) of patients improve in both TTP and FWHM measurements, and whereof 57% (8/14) improve more noticeably on FWHM. TTP is in good agreement with Tmax in estimating bolus delay. Our study data also suggest bolus dispersion estimated by FWHM is an additional, informative indicator in pediatric MMD monitoring. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/554479 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-80036-3 | SDG/Keyword: | contrast medium; spin label; adolescent; adult; brain circulation; child; female; hemodynamics; human; magnetic resonance angiography; male; moyamoya disease; nuclear magnetic resonance imaging; pathology; physiologic monitoring; preschool child; procedures; retrospective study; young adult; Adolescent; Adult; Cerebrovascular Circulation; Child; Child, Preschool; Contrast Media; Female; Hemodynamics; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Monitoring, Physiologic; Moyamoya Disease; Retrospective Studies; Spin Labels; Young Adult |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.