https://scholars.lib.ntu.edu.tw/handle/123456789/556694
標題: | Association between periodontitis and anti-cardiolipin antibodies in Buerger disease | 作者: | YI-WEN CHEN Nagasawa T. Wara-Aswapati N. Ushida Y. Wang D. Takeuchi Y. Kobayashi H. Umeda M. Inoue Y. Iwai T. Ishikawa I. Izumi Y. |
關鍵字: | β-2-glycoprotein I; Anti-cardiolipin antibody; Buerger disease; Molecular mimicry; Periodontitis | 公開日期: | 2009 | 卷: | 36 | 期: | 10 | 起(迄)頁: | 830-835 | 來源出版物: | Journal of Clinical Periodontology | 摘要: | Aim: Anti-cardiolipin (CL) antibodies can be induced in Buerger disease (BD), an inflammatory occlusive disorder affecting peripheral blood vessels, in response to bacteria bearing homology to the TLRVYK peptide of a phospholipid-binding plasma protein β-2-glycoprotein I. TLRVYK homologies are present in Porphyromonas gingivalis (TLRIYT) and Treponema denticola (TLALYK). This study investigated the association between periodontal infection and anti-CL antibodies in BD patients. Material and Methods: Periodontal conditions were examined in 19 BD patients and 25 systemically healthy control subjects. All subjects were heavy smokers. Serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies were assessed using the enzyme-linked immunosorbent assay. Results: BD patients had a significantly higher prevalence of periodontitis, more severe periodontal destruction and increased titres of serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies compared with healthy subjects. The levels of anti-CL antibodies positively correlated with those of the three anti-peptide antibodies. Anti-CL antibody titres were significantly associated with the percentage of sites with clinical attachment level ?4 mm in BD patients. Conclusion: Elevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein. ? 2009 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349144862&doi=10.1111%2fj.1600-051X.2009.01467.x&partnerID=40&md5=7979ae5423f35d1694987d372bc15098 https://scholars.lib.ntu.edu.tw/handle/123456789/556694 |
ISSN: | 0303-6979 | DOI: | 10.1111/j.1600-051X.2009.01467.x | SDG/關鍵字: | adhesin; argingipain, Porphyromonas gingivalis; bacterium antibody; beta2 glycoprotein 1; cardiolipin antibody; cysteine proteinase; immunoglobulin G; immunologic factor; outer membrane protein; phosphoglycerate kinase; TLR protein, bacteria; beta2 glycoprotein 1; article; blood; Buerger disease; case control study; classification; comparative study; female; human; immunology; male; middle aged; molecular mimicry; periodontal disease; periodontal pocket; periodontitis; Porphyromonas gingivalis; risk factor; sequence homology; smoking; Treponema denticola; Adhesins, Bacterial; Antibodies, Anticardiolipin; Antibodies, Bacterial; Bacterial Outer Membrane Proteins; beta 2-Glycoprotein I; Case-Control Studies; Cysteine Endopeptidases; Female; Humans; Immunoglobulin G; Immunologic Factors; Male; Middle Aged; Molecular Mimicry; Periodontal Attachment Loss; Periodontal Pocket; Periodontitis; Phosphoglycerate Kinase; Porphyromonas gingivalis; Risk Factors; Sequence Homology, Amino Acid; Smoking; Thromboangiitis Obliterans; Treponema denticola |
顯示於: | 牙醫學系 |
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