https://scholars.lib.ntu.edu.tw/handle/123456789/557016
標題: | Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia | 作者: | Tseng, Huai-Hsuan HAI-GWO HWU CHEN-CHUNG LIU Chen, Sue-Huei CHIH-MIN LIU MING-HSIEN HSIEH SUE-HUEI CHEN Howes, Oliver YI-TING LIN Hsieh, Ming H. Liu, Chen-Chung Shan, Jia-Chi Lin, Yi-Ting |
公開日期: | 2013 | 卷: | 8 | 期: | 6 | 起(迄)頁: | e66571 | 來源出版物: | PLoS ONE | 摘要: | Background:Patients with schizophrenia perform significantly worse on emotion recognition tasks than healthy participants across several sensory modalities. Emotion recognition abilities are correlated with the severity of clinical symptoms, particularly negative symptoms. However, the relationships between specific deficits of emotion recognition across sensory modalities and the presentation of psychotic symptoms remain unclear. The current study aims to explore how emotion recognition ability across modalities and neurocognitive function correlate with clusters of psychotic symptoms in patients with schizophrenia.Methods:111 participants who met the DSM-IV diagnostic criteria for schizophrenia and 70 healthy participants performed on a dual-modality emotion recognition task, the Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW), and selected subscales of WAIS-III. Of all, 92 patients received neurocognitive evaluations, including CPT and WCST. These patients also received the PANSS for clinical evaluation of symptomatology.Results:The emotion recognition ability of patients with schizophrenia was significantly worse than healthy participants in both facial and vocal modalities, particularly fearful emotion. An inverse correlation was noted between PANSS total score and recognition accuracy for happy emotion. The difficulty of happy emotion recognition and earlier age of onset, together with the perseveration error in WCST predicted total PANSS score. Furthermore, accuracy of happy emotion and the age of onset were the only two significant predictors of delusion/hallucination. All the associations with happy emotion recognition primarily concerned happy prosody.Discussion:Deficits in emotional processing in specific categories, i.e. in happy emotion, together with deficit in executive function, may reflect dysfunction of brain systems underlying severity of psychotic symptoms, in particular the positive dimension. ? 2013 Tseng et al. |
URI: | 2-s2.0-84879260255 https://scholars.lib.ntu.edu.tw/handle/123456789/557016 |
ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0066571 | SDG/關鍵字: | amfebutamone; amisulpride; aripiprazole; chlorpromazine; clozapine; fluoxetine; flupentixol; fluphenazine decanoate; fluvoxamine; haloperidol; mirtazapine; moclobemide; olanzapine; quetiapine; risperidone; sertraline; sulpiride; trazodone; trifluoperazine; valproic acid; venlafaxine; ziprasidone; zotepine; adult; article; cognitive defect; Continuous Performance Test; controlled study; correlation analysis; delusion; diagnostic accuracy; Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version; disease association; disease severity; DSM-IV; dual-modality emotion recognition task; emotion; emotion recognition; executive function; face; facial recognition; female; hallucination; happiness; human; major clinical study; male; onset age; perseveration; prediction; psychologic assessment; psychosis; recognition; schizophrenia; scoring system; symptomatology; Wechsler Intelligence Scale; Wisconsin Card Sorting Test; Adult; Analysis of Variance; Antipsychotic Agents; Emotions; Facial Expression; Female; Humans; Male; Middle Aged; Pattern Recognition, Visual; Psychiatric Status Rating Scales; Psychomotor Performance; Psychotic Disorders; Reaction Time; Regression Analysis; Schizophrenia; Schizophrenic Psychology; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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