|Title:||The genetic effect and molecular function of the SOCS5 in the prognosis of esophageal squamous cell carcinoma||Authors:||Yang, Pei Wen
Chang, Ya Han
Wong, Li Fan
Lin, Ching Ching
|Keywords:||epidermal growth factor receptor (EGFR) | esophageal cancer | esophageal squamous cell carcinoma (ESCC) | single nucleotide polymorphisms (SNPs) | suppressor of cytokine signaling-5 (SOCS5);epidermal growth factor receptor (EGFR); esophageal cancer; esophageal squamous cell carcinoma (ESCC); single nucleotide polymorphisms (SNPs); suppressor of cytokine signaling-5 (SOCS5)||Issue Date:||1-Jan-2021||Journal Volume:||12||Journal Issue:||8||Source:||Journal of Cancer||Abstract:||
Expression of cytokines and growth factors have been shown to be highly correlated with the prognosis of esophageal squamous cell carcinoma (ESCC), a deadly disease with poor prognosis. The suppressor of cytokine signaling (SOCS) family of proteins are key factors in regulating cytokines and growth factors. Yet the role of the SOCS proteins in ESCC is hardly investigated. We currently investigated the prognostic role of SOCS5 in ESCC. We analyzed the prognostic effects of 16 single nucleotide polymorphisms (SNPs) within the SOCS genes in 632 ESCC patients. We repeatedly observed that the 3 SNPs in SOCS5, SOCS5:rs3814039, SOCS5:rs3738890, and SOCS5: rs3768720, were significantly correlated with both overall (OS) and progression-free survival (PFS) of ESCC patients (rs3814039, p=0.032 for OS and p=0.009 for PFS; rs3738890, p=0.016 for OS, and p=0.008 for PFS; rs3768720, p=0.005 for OS and p=0.002 for PFS). SOCS5: rs3768720 was also significantly associated with distant metastasis (Ptrend=0.028). The luciferase assay revealed that SOCS5:rs3814039 and SOCS5: rs3768720 might influence the prognosis by regulating SOCS5 expression. Functional analysis demonstrated SOCS5 was able to regulate epidermal growth factor receptor (EGFR) expression and migration activity of ESCC cells. Furthermore, Patients with strong SOCS5 in normal tissues exhibited significantly better PFS (P=0.049) and reduced risk of distant metastasis (P=0.004) compared to those with weak SOCS5 expression. Overall, our study demonstrates the novel function of SOCS5 in ESCC prognosis. The genetic polymorphisms and expression of SOCS5 could serve as a novel therapeutic biomarker for improving the prognosis of ESCC.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/557205||DOI:||10.7150/jca.51806||metadata.dc.subject.other:||benzyloxycarbonylleucylleucylleucinal; epidermal growth factor receptor; genomic DNA; suppressor of cytokine signaling; suppressor of cytokine signaling 5; unclassified drug; adult; aged; Article; cancer prognosis; cancer staging; cell migration; chemoradiotherapy; controlled study; distant metastasis; esophageal squamous cell carcinoma; esophageal squamous cell carcinoma cell line; esophagus resection; female; heredity; human; human cell; human tissue; major clinical study; male; middle aged; overall survival; pediatric patient; peripheral blood mononuclear cell; progression free survival; protein expression; protein function; retrospective study; single nucleotide polymorphism; transient transfection
|Appears in Collections:||病理學科所|
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