https://scholars.lib.ntu.edu.tw/handle/123456789/557578
標題: | Prevalence of hepatitis C viral infection in a community in Taiwan. Detection by synthetic peptide-based assay and polymerase chain reaction | 作者: | JIN-CHUAN SHEU Wang, Jin-Town Wang T.-H. Wang C.-Y. PEI-MING YANG GUAN-TARN HUANG Shih L.-N. Lee, Hsuan-Shu DING-SHINN CHEN |
公開日期: | 1993 | 卷: | 17 | 期: | 2 | 起(迄)頁: | 192-198 | 來源出版物: | Journal of Hepatology | 摘要: | The prevalence of antibodies to hepatitis C virus (anti-HCV) in a hepatitis B virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. A general population of 1500 from Northern Taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural protein region as the solid-phase antigen. A total of 37 subjects out of 1500 (2.5%) were positive, with no significant difference in distribution between hepatitis B antigenemic and non-antigenemic samples. The prevalence of anti-HCV was higher in subjects with abnormal than those with normal liver function tests (8.2% vs. 1.5%). Prevalence increased with age. By polymerase chain reaction, 43% of anti-HCV-positive samples were HCV-RNA-positive. However, only 1 (0.6%) of 150 anti-HCV-negative subjects had HCV-RNA. Comparison of the results with those from a conventional recombinant C100-3-based assay showed that the capsid/non-structural region synthetic antigen system provided more accurate sensitivity and specificity. The more sensitive assay revealed a high prevalence for HCV infection of 2.5% among this general population in Taiwan. ? 1993 Elsevier Scientific Publishers Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027458404&doi=10.1016%2fS0168-8278%2805%2980037-6&partnerID=40&md5=90bc6f168311ed7d0cec84c936392416 https://scholars.lib.ntu.edu.tw/handle/123456789/557578 |
ISSN: | 0168-8278 | DOI: | 10.1016/S0168-8278(05)80037-6 | SDG/關鍵字: | hepatitis c antibody; virus rna; adult; aged; article; controlled study; enzyme immunoassay; female; hepatitis c; human; major clinical study; male; polymerase chain reaction; priority journal; taiwan; Adult; Aged; Base Sequence; Female; Hepacivirus; Hepatitis Antibodies; Hepatitis C; Human; Immunoenzyme Techniques; Male; Middle Age; Molecular Sequence Data; Polymerase Chain Reaction; Prevalence; Random Allocation; Support, Non-U.S. Gov't; Taiwan |
顯示於: | 醫學系 |
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