https://scholars.lib.ntu.edu.tw/handle/123456789/557656
Title: | Predominant role of Haemophilus influenzae in the association of conjunctivitis, acute otitis media and acute bacterial paranasal sinusitis in children | Authors: | Hu, Ya-Li PING-ING LEE PO-REN HSUEH CHUN-YI LU LUAN-YIN CHANG LI-MIN HUANG Chang, Tu-Hsuan JONG-MIN CHEN |
Issue Date: | 8-Jan-2021 | Journal Volume: | 11 | Journal Issue: | 1 | Source: | Scientific reports | Abstract: | Haemophilus influenzae is a predominant pathogen for conjunctivitis, acute otitis media and acute bacterial paranasal sinusitis in children. We undertook this study to investigate the possible association among these diseases. Children younger than 18-year-old with a diagnosis of bacterial conjunctivitis plus acute otitis media and/or acute bacterial paranasal sinusitis during 2009-2018 were included. Sampling for bacterial cultures was obtained from the lower palpebral conjunctiva and/or ear discharge with cotton-tipped swabs. A total of 67 children were recruited and the age was 29.5 (± 22.4) months in average. Fifty-seven children had conjunctivitis-otitis media syndrome and eight of them had a concurrent diagnosis of acute paranasal sinusitis. Ten children had conjunctivitis and acute paranasal sinusitis simultaneously. Clusters in household were observed in 50.7% children. Most common isolates were Haemophilus influenzae (70%), Moraxella catarrhalis (18%), and Staphylococcus aureus (8%). Antibiotic resistance rate of H. influenzae was 80% for ampicillin, 18% for amoxicillin-clavulanate, and 11% for the second or third-generation cephalosporins. Apart from well-known conjunctivitis-otitis media syndrome, acute paranasal sinusitis may also be linked to conjunctivitis with a similar pathogenic process. Simultaneous presence of these infections may guide the choice of empiric antibiotics toward H. influenzae. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/557656 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-79680-6 | SDG/Keyword: | [SDGs]SDG3 acute disease; antibiotic resistance; bacterial conjunctivitis; child; drug effect; female; Haemophilus infection; Haemophilus influenzae; human; infant; isolation and purification; male; microbial sensitivity test; microbiology; otitis media; pathogenicity; preschool child; sinusitis; Acute Disease; Child; Child, Preschool; Conjunctivitis, Bacterial; Drug Resistance, Microbial; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Male; Microbial Sensitivity Tests; Otitis Media; Sinusitis |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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