https://scholars.lib.ntu.edu.tw/handle/123456789/557665
標題: | A novel DNA chromatography method to discriminate Mycobacterium abscessus subspecies and macrolide susceptibility | 作者: | Yoshida, Mitsunori Sano, Sotaro JUNG-YIEN CHIEN Fukano, Hanako Suzuki, Masato Asakura, Takanori Morimoto, Kozo Murase, Yoshiro Miyamoto, Shigehiko Kurashima, Atsuyuki Hasegawa, Naoki PO-REN HSUEH Mitarai, Satoshi Ato, Manabu Hoshino, Yoshihiko |
關鍵字: | ATS/ERS/ESCMID/IDSA guideline; DNA chromatography; Drug susceptibility; Non-tuberculosis mycobacteria; Subspecies discrimination; Whole genome sequencing | 公開日期: | 二月-2021 | 卷: | 64 | 來源出版物: | EBioMedicine | 摘要: | The clinical impact of infection with Mycobacterium (M.) abscessus complex (MABC), a group of emerging non-tuberculosis mycobacteria (NTM), is increasing. M. abscessus subsp. abscessus/bolletii frequently shows natural resistance to macrolide antibiotics, whereas M. abscessus subsp. massiliense is generally susceptible. Therefore, rapid and accurate discrimination of macrolide-susceptible MABC subgroups is required for effective clinical decisions about macrolide treatments for MABC infection. We aimed to develop a simple and rapid diagnostic that can identify MABC isolates showing macrolide susceptibility. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/557665 | ISSN: | 23523964 | DOI: | 10.1016/j.ebiom.2020.103187 | SDG/關鍵字: | azithromycin; clarithromycin; erythromycin; macrolide; RNA 16S; antiinfective agent; DNA; macrolide; antibiotic resistance; Article; bacterial strain; bacterium isolate; chromatography; DNA extraction; DNA sequence; drug sensitivity; genetic marker; genotype; limit of detection; multiplex polymerase chain reaction; Mycobacterium abscessus; nonhuman; phylogeny; polymerase chain reaction; sensitivity and specificity; sequence analysis; Taiwan; whole genome sequencing; bacterial gene; chromatography; classification; drug effect; genetics; human; microbial sensitivity test; Mycobacterium abscessus; procedures; Anti-Bacterial Agents; Chromatography; DNA; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Macrolides; Microbial Sensitivity Tests; Mycobacterium abscessus; Phylogeny; Polymerase Chain Reaction |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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