https://scholars.lib.ntu.edu.tw/handle/123456789/558029
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KUEN-CHEH YANG | en_US |
dc.contributor.author | Hung H.-F. | en_US |
dc.contributor.author | CHIA-WEN LU | en_US |
dc.contributor.author | HAO-HSIANG CHANG | en_US |
dc.contributor.author | Lee L.-T. | en_US |
dc.contributor.author | KUO-CHIN HUANG | en_US |
dc.date.accessioned | 2021-04-28T07:59:29Z | - |
dc.date.available | 2021-04-28T07:59:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84973380277&doi=10.1038%2fsrep27034&partnerID=40&md5=7fce72659e7e92e78648eb28ca60717c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/558029 | - |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is an emerging chronic liver disease that may lead to liver cirrhosis and hepatocellular carcinoma. We aimed to determine the association between the prevalence of metabolic syndrome (MetS) and NAFLD severity using semi-quantitative ultrasonography (US). A total of 614 participants were recruited from the community. NAFLD was evaluated according to the ultrasonographic Fatty Liver Indicator (US-FLI), which is a semi-quantitative liver ultrasound score. Insulin resistance was estimated with the homeostasis model assessment index for insulin resistance (HOMA-IR). NAFLD and MetS were found in 53.7 and 17.3% of the participants, respectively. Linear relationships were found between the severity of NAFLD and waist circumference, fasting glucose, HOMA-IR, triglycerides, HDL-C and blood pressure. After adjusting for confounding factors, i.e., body mass index and HOMA-IR, the odds ratios for MetS were 3.64 (95% confidence interval (CI): 1.5-8.83) for those with mild NAFLD and 9.4 (95% CI: 3.54-24.98) for those with moderate-to-severe NAFLD compared to those without NAFLD. The combination of the HOMA-IR and US-FLI scores better differentiated MetS than the HOMA-IR alone. In addition to obesity, the severity of NAFLD and the HOMA-IR both play important roles in MetS. Whether NAFLD is a component of MetS warrants further research. | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | insulin; triacylglycerol; abdominal obesity; adult; blood; body mass; China; complication; diagnostic imaging; echography; female; human; insulin resistance; male; metabolic syndrome X; middle aged; nonalcoholic fatty liver; odds ratio; pathology; prevalence; risk factor; severity of illness index; waist circumference; Adult; Body Mass Index; China; Female; Humans; Insulin; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity, Abdominal; Odds Ratio; Prevalence; Risk Factors; Severity of Illness Index; Triglycerides; Ultrasonography; Waist Circumference | - |
dc.title | Association of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome Independently of Central Obesity and Insulin Resistance | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/srep27034 | - |
dc.identifier.pmid | 27246655 | - |
dc.identifier.scopus | 2-s2.0-84973380277 | - |
dc.relation.pages | 27034 | en_US |
dc.relation.journalvolume | 6 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Psychology | - |
crisitem.author.orcid | 0000-0003-0047-2238 | - |
crisitem.author.orcid | 0000-0001-7555-1737 | - |
crisitem.author.orcid | 0000-0001-5836-0728 | - |
crisitem.author.orcid | 0000-0002-6029-5520 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 醫學系 |
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