https://scholars.lib.ntu.edu.tw/handle/123456789/558209
標題: | Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA) | 作者: | Hosgood H.D. III, Song M. Hsiung C.A. Yin Z. Shu X.-O. Wang Z. Chatterjee N. Zheng W. Caporaso N. Burdette L. Yeager M. Berndt S.I. Landi M.T. Chen C.-J. Chang G.-C. Hsiao C.-F. Tsai Y.-H. Chien L.-H. KUAN-YU CHEN Huang M.-S. Su W.-C. Chen Y.-M. Chen C.-H. Yang T.-Y. Wang C.-L. Hung J.-Y. Lin C.-C. Perng R.-P. Chen C.-Y. Chen K.-C. Li Y.-J. CHONG-JEN YU Chen Y.-S. Chen Y.-H. Tsai F.-Y. Kim C. Seow W.J. Bassig B.A. Wu W. Guan P. He Q. Gao Y.-T. Cai Q. Chow W.-H. Xiang Y.-B. Lin D. Wu C. Wu Y.-L. Shin M.-H. Hong Y.-C. Matsuo K. Chen K. Wong M.P. Lu D. Jin L. Wang J.-C. Seow A. Wu T. Shen H. Fraumeni J.F. Jr. PAN-CHYR YANG Chang I.-S. Zhou B. Chanock S.J. Rothman N. Lan Q. |
公開日期: | 2015 | 出版社: | Springer Verlag | 卷: | 134 | 期: | 3 | 起(迄)頁: | 333-341 | 來源出版物: | Human Genetics | 摘要: | We previously carried out a multi-stage genome-wide association study (GWAS) on lung cancer among never smokers in the Female Lung Cancer Consortium in Asia (FLCCA) (6,609 cases, 7,457 controls) that identified novel susceptibility loci at 10q25.2, 6q22.2, and 6p21.32, and confirmed two previously identified loci at 5p15.33 and 3q28. Household air pollution (HAP) attributed to solid fuel burning for heating and cooking, is the leading cause of the overall disease burden in Southeast Asia, and is known to contain lung carcinogens. To evaluate the gene–HAP interactions associated with lung cancer in loci independent of smoking, we analyzed data from studies participating in FLCCA with fuel use information available (n?=?3; 1,731 cases; 1,349 controls). Coal use was associated with a 30?% increased risk of lung cancer (OR?1.3, 95?% CI?1.0–1.6). Among the five a priori SNPs identified by our GWAS, two showed a significant interaction with coal use (HLA Class II rs2395185, p?=?0.02; TP63 rs4488809 (rs4600802), p?=?0.04). The risk of lung cancer associated with coal exposure varied with the respective alleles for these two SNPs. Our observations provide evidence that genetic variation in HLA Class II and TP63 may modify the association between HAP and lung cancer risk. The roles played in the cell cycle and inflammation pathways by the proteins encoded by these two genes provide biological plausibility for these interactions; however, additional replication studies are needed in other non-smoking populations. ? 2015, Springer-Verlag Berlin Heidelberg (outside the USA). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938223536&doi=10.1007%2fs00439-014-1528-z&partnerID=40&md5=15dfb19a9af9af873c2440dfe732340e https://scholars.lib.ntu.edu.tw/handle/123456789/558209 |
ISSN: | 0340-6717 | DOI: | 10.1007/s00439-014-1528-z | SDG/關鍵字: | coal; fuel; HLA antigen class 2; air pollutant; genetic marker; adult; air pollution; Article; cancer risk; cancer susceptibility; controlled study; cooking; female; genetic association; genetic variability; genotype environment interaction; heating; household; household air pollution; human; lung cancer; major clinical study; middle aged; oncogene; priority journal; single nucleotide polymorphism; smoking; TP63 gene; adenocarcinoma; aged; air pollutant; case control study; chemically induced; genetic marker; genetic predisposition; genetics; genome-wide association study; indoor air pollution; lung tumor; risk; toxicity; Adenocarcinoma; Adult; Aged; Air Pollutants; Air Pollution, Indoor; Case-Control Studies; Female; Gene-Environment Interaction; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lung Neoplasms; Middle Aged; Polymorphism, Single Nucleotide; Risk |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。