https://scholars.lib.ntu.edu.tw/handle/123456789/559517
標題: | Emission-related heavy metal associated with oxidative stress in children: Effect of antioxidant intake Killian B. Yuan T.-H. Tsai C.-H. Chiu T.H.T. Chen Y.-H. CHANG-CHUAN CHAN |
作者: | Killian B. Yuan T.-H. Tsai C.-H. Chiu T.H.T. Chen Y.-H. CHANG-CHUAN CHAN |
關鍵字: | Antioxidants; Heavy metals; Industrial pollution; Oxidative stress; Young children | 公開日期: | 2020 | 出版社: | MDPI AG | 卷: | 17 | 期: | 11 | 來源出版物: | International Journal of Environmental Research and Public Health | 摘要: | Heavy metals, the common pollutants emitted from industrial activities, are believed to cause harmful effects, partially through the mechanism of elevated oxidative stress, and antioxidant intake has been hypothesized to provide a potential protective effect against oxidative stress. This study aims to investigate the heavy metal exposure and the associated oxidative damage of young children living near a petrochemical complex and to assess the protective effect of antioxidant intake. There were 168 children recruited from the kindergartens near a huge petrochemical complex, with 87 as the high exposure group and 81 as the low exposure group. Urinary concentrations of eleven metals were detected by inductively coupled plasma mass spectrometry, and four biomarkers of oxidative stress were measured in urine by liquid chromatography-tandem mass spectrometry. The food frequency questionnaire was collected to assess participants’ intake of antioxidants. Multiple linear regression was performed to determine the predictors of metals for oxidative stress and to measure the beneficial effect of antioxidants. Weighted quantile sum regression was performed to determine the contributors among metals to the oxidative stress. Results showed that high exposure group had significantly higher concentrations of chromium, manganese, nickel, arsenic, strontium, cadmium, and lead when compared to those in low exposure group. There was no obviously difference on the total antioxidant intake and dietary profile between two groups. The elevated levels of two oxidative stress markers were significantly associated with most of the urinary metal concentrations in all study subjects after adjusting confounders, while no significant association was found between oxidative stress and antioxidant intake. Among the metals, mercury and strontium showed the dominated contributions for elevated levels of oxidative stress. It concluded that higher metal exposure was associated with elevated oxidative stress but with no protective effect by antioxidant intake among the young children residents near a petrochemical industry. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085875261&doi=10.3390%2fijerph17113920&partnerID=40&md5=837c6c412c04781146df6d684bbc6682 https://scholars.lib.ntu.edu.tw/handle/123456789/559517 |
ISSN: | 1661-7827 | DOI: | 10.3390/ijerph17113920 | SDG/關鍵字: | 4 hydroxy 2 nonenal mercapturic acid; 4 hydroxynonenal; 8 hydroxydeoxyguanosine; 8 isoprostaglandin F2 alpha; 8 nitroguanine; acetylcysteine; antioxidant; arsenic; cadmium; chromium; copper; heavy metal; lead; manganese; mercury; nickel; strontium; thallium; unclassified drug; vanadium; antioxidant; biomarker; child health; concentration (composition); health impact; health risk; heavy metal; industrial emission; oxidative stress; petrochemical industry; pollution effect; urine; Article; child; child nutrition; controlled study; dietary intake; environmental exposure; female; food frequency questionnaire; human; inductively coupled plasma mass spectrometry; kindergarten; liquid chromatography-mass spectrometry; male; oxidative stress; pollution; urine level; diet; environmental exposure; oxidative stress; pollutant; preschool child; Antioxidants; Arsenic; Child; Child, Preschool; Diet; Environmental Exposure; Environmental Pollutants; Humans; Metals, Heavy; Oxidative Stress |
顯示於: | 環境與職業健康科學研究所 |
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