https://scholars.lib.ntu.edu.tw/handle/123456789/559924
標題: | Perfusion of residual viable myocardium in nontransmural infarct zone after intervention: MR quantitative myocardial blood flow measurement | 作者: | MAO-YUAN SU BAI-CHIN LEE YEN-WEN WU HSI-YU YU Chu W.-C. WEN-YIH TSENG |
公開日期: | 2008 | 卷: | 249 | 期: | 3 | 起(迄)頁: | 820-828 | 來源出版物: | Radiology | 摘要: | Purpose: To assess regional myocardial perfusion in patients with chronic myocardial infarction (MI) in relationship to the extent of residual viable myocardium. Materials and Methods:The study was approved by the local ethics committee; written informed consent was obtained from each participant. Twenty-nine patients with first onset of MI who underwent successful primary percutaneous coronary intervention at least 6 months thereafter were studied. Delayed enhancement magnetic resonance (MR) imaging was performed to define the infarct zone and its viable myocardial ratio (VMR), quantified by the percentage of the non- scarred pixels relative to the total pixels in the infarct zone. First-pass contrast material-enhanced MR imaging was performed to estimate regional perfusion and myocar- dial perfusion reserve (MPR) in the infarct region. Paired comparisons in perfusion and MPR were tested with non-parametric Wilcoxon matched-pairs test. A difference with P < .05 was considered significant. Correlation was tested with Pearson analysis. Results: The infarct region showed significant impairment of regional perfusion at rest (mean, 0.966 [mL · min-1]/g ± 0.271 [standard deviation] vs 1.151 [mL · min-1]/g ± 0.282; P = .024) and during stress (mean, 1.789 [mL · min-1]/g ± 0.732 vs 2.753 [mL · min-1]/g ± 0.806; P < .0001) and a reduced MPR (mean, 1.923 ± 0.678 vs 2.486 ± 0.836; P < .0001) as compared with remote myocardium. The estimated perfusion, with stress, of the residual viable myocardium was preserved (2.993 [mL · min-1]/g ± 1.451 vs 2.753 [mL · min-1]/g ± 0.806), and the difference was not significant. Furthermore, stress perfusion (R = 0.385; P = .039) and MPR (R = 0.434; P = .018) in the infarct zone were significantly correlated with VMR, suggesting that preservation of myocardial perfu- sion in the infarct region reflects the amount of viable myocardium. Conclusion: Reduced perfusion in the infarct zone is related to the extent of the viable myocardium. ? RSNA, 2008. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149180490&doi=10.1148%2fradiol.2493080099&partnerID=40&md5=5401d8c48071c7fbbff2f6a041d215fc https://scholars.lib.ntu.edu.tw/handle/123456789/559924 |
ISSN: | 0033-8419 | DOI: | 10.1148/radiol.2493080099 | SDG/關鍵字: | adult; article; chronic disease; clinical article; coronary artery blood flow; heart infarction; heart infarction size; heart muscle perfusion; human; male; nuclear magnetic resonance imaging; percutaneous coronary intervention; priority journal; coronary artery blood flow; middle aged; nuclear magnetic resonance imaging; pathophysiology; tissue survival; transluminal coronary angioplasty; Angioplasty, Transluminal, Percutaneous Coronary; Coronary Circulation; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Tissue Survival |
顯示於: | 醫學系 |
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