https://scholars.lib.ntu.edu.tw/handle/123456789/560908
標題: | Clinical Characteristics and Outcome of Morbidly Obese Bariatric Patients with Concurrent Hepatitis C Viral Infection | 作者: | MING-LUN HAN Lee, W.-J. Chen, J.-C. Ser, K.-H. Chen, S.-C. JEN-CHIH CHEN |
公開日期: | 2019 | 卷: | 29 | 期: | 3 | 起(迄)頁: | 828-834 | 來源出版物: | Obesity Surgery | 摘要: | Background: Hepatitis C virus (HCV) is an important cause of liver cirrhosis and its complications. The safety and efficacy of bariatric surgery in patients with HCV infection is not clear. Methods: Charts were reviewed to identify patients with HCV infection before bariatric surgery. Bariatric surgical patients with non-alcoholic steatohepatitis (NASH) and without NASH (non-NASH) were recruited as comparative groups. Demographic variables, perioperative data, follow-up, and HCV-related parameters were extracted and compared. Results: Forty-seven bariatric patients between 2000 and 2016 that suffered from HCV infection were identified. The mean age and body mass index (BMI) at baseline were 34.5 ± 9.9?years and 40.4 ± 7.7?kg/m 2 , respectively. The HCV(+) group was associated with female sex, older age, lower BMI, and waist circumference than both NASH and non-NASH groups. Both HCV(+) and NASH groups had higher liver function tests and incidence of metabolic syndrome than non-NASH group. The HCV(+) group had lower uric acid and albumin level than the NASH group. Early major postoperative complication occurred in 1 (2.1%) patient of the HCV(+) group. At follow-up, the mean BMI decreased to 29.1 ± 7.1?kg/m 2 and total weight loss was 25% for the HCV(+) group at 5?years after surgery. The weight loss curves were similar between the HCV(+) group and NASH group. During follow-up, no patients died but one patient with HCV(+) developed flare up of hepatitis after gastric bypass. The mean liver transaminase level remained in normal range for the HCV(+) group. Conclusion: Co-existence of HCV infection does not influence the outcome of bariatric surgery but continued monitoring of the liver function is indicated. ? 2018, Springer Science+Business Media, LLC, part of Springer Nature. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/560908 | ISSN: | 0960-8923 | DOI: | 10.1007/s11695-018-3615-z | SDG/關鍵字: | alanine aminotransferase; albumin; aspartate aminotransferase; cholesterol; gamma glutamyltransferase; glucose; hemoglobin A1c; insulin; low density lipoprotein; peginterferon; ribavirin; triacylglycerol; uric acid; adult; age; alanine aminotransferase blood level; albumin blood level; antiviral therapy; Article; aspartate aminotransferase blood level; bariatric surgery; blood pressure; body mass; body weight loss; cholesterol blood level; clinical article; clinical feature; clinical outcome; concurrent infection; disease severity; female; follow up; gamma glutamyl transferase blood level; gastric bypass surgery; glucose blood level; hepatitis C; human; hypoproteinemia; insulin blood level; liver cirrhosis; liver function test; male; malnutrition; medical record review; metabolic syndrome X; morbid obesity; nonalcoholic fatty liver; priority journal; sleeve gastrectomy; triacylglycerol blood level; uric acid blood level; waist circumference; adverse event; bariatric surgery; complication; hepatitis C; morbid obesity; procedures; retrospective study; young adult; Adult; Bariatric Surgery; Female; Hepatitis C; Humans; Male; Obesity, Morbid; Retrospective Studies; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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