https://scholars.lib.ntu.edu.tw/handle/123456789/561118
標題: | Increased rifampicin resistance in blood isolates of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients exposed to rifampicin-containing antituberculous treatment | 作者: | Tan C.-K. Lai C.-C. Liao C.-H. Lin S.-H. YU-TSUNG HUANG PO-REN HSUEH |
公開日期: | 2011 | 卷: | 37 | 期: | 6 | 起(迄)頁: | 550-553 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | The aim of this study was to determine the rifampicin (RIF) resistance rate of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients with MRSA bacteraemia who have or have not been exposed to RIF-containing antituberculous (anti-TB) treatment. From 2000 to 2008, patients with MRSA bacteraemia and previous exposure to RIF-containing anti-TB therapy were selected. Patients matched for sex, age and time of culture of MRSA bacteraemia but without exposure to anti-TB therapy were selected as a control group. A total of 139 patients, comprising 49 with RIF exposure and 90 without RIF exposure, were analysed. The RIF resistance rate was higher in patients with previous RIF exposure (61.2% vs. 20.0%; P < 0.001). The minimum inhibitory concentration of RIF that inhibited 50% of MRSA isolates (MIC50) for the study group was also higher (128 mg/L vs. 0.015 mg/L; P < 0.001). The mortality rate was higher in the study group (59.2% vs. 41.1%; P = 0.041). MRSA isolates recovered from patients with current usage of a RIF-containing anti-TB regimen were more likely to be resistant to RIF (87.5% vs. 36%; P = 0.001), with higher MIC50 values (256 mg/L vs. 1 mg/L; P = 0.002), and resulted in a higher mortality rate than isolates from patients with remote usage of an anti-TB regimen (79.2% vs. 40%; P = 0.005). Multivariate analysis showed that current anti-TB drug usage was the only risk factor for RIF resistance [odds ratio (OR) = 7.457, 95% confidence interval (CI) 1.581-35.167] and mortality (OR = 7.201, 95% CI 1.583-32.766). Given the high rate of RIF resistance in patients with prior anti-TB treatment, RIF susceptibility testing should be performed before considering combination treatment of RIF in MRSA infection. ? 2011 Elsevier B.V. and the International Society of Chemotherapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561118 | ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2011.01.018 | SDG/關鍵字: | clindamycin; cotrimoxazole; erythromycin; gentamicin; minocycline; rifampicin; aged; antibiotic resistance; article; bacterium isolate; controlled study; drug exposure; drug use; female; human; major clinical study; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; minimum inhibitory concentration; mortality; Mycobacterium tuberculosis; nonhuman; priority journal; pulsed field gel electrophoresis; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Blood; Drug Resistance, Bacterial; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Rifampin; Staphylococcal Infections; Tuberculosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。