https://scholars.lib.ntu.edu.tw/handle/123456789/561177
標題: | Diagnostic performance of an enzyme-linked immunospot assay for interferon-γ in extrapulmonary tuberculosis varies between different sites of disease | 作者: | Liao C.H. Chou C.H. Lai C.C. YU-TSUNG HUANG Tan C.K. Hsu H.L. PO-REN HSUEH |
公開日期: | 2009 | 卷: | 59 | 期: | 6 | 起(迄)頁: | 402-408 | 來源出版物: | Journal of Infection | 摘要: | Objectives: To evaluate diagnostic performance of an enzyme-linked immunospot assay for interferon-γ (T SPOT-TB) in patients with suspected extrapulmonary tuberculosis (TB). Methods: From January 2007 to December 2008, patients with suspected extrapulmonary TB were prospectively enrolled from 2 tertiary care hospitals. Results: A total of 138 patients with suspected extrapulmonary TB were enrolled; 50 patients had positive culture for Mycobacterium tuberculosis and 39 patients had probable TB. The sites of infection were lymph node (n = 20), pleura (n = 19), bone/joint (n = 15), urinary tract (n = 7), peritoneum (n = 7), meninges (n = 6), disseminated (n = 5), intestine (n = 3), pericardium (n = 2), skin (n = 2), throat (n = 1), neck (n = 1), and genitalia (n = 1). The overall sensitivity and specificity were 79.8% (71/89) and 81.6% (40/49). The sensitivity ranged from 100% for tuberculous meningitis, tuberculous pericarditis, and intestinal TB, 95% for lymphadenitis, to 42.9% for tuberculous peritonitis. The sensitivity of the T?SPOT-TB assay was 70.6% in immunocompromised patients and 85.5% in immunocompetent patients (p = 0.09). Conclusions: The T SPOT-TB assay can be a useful tool for diagnosing extra-pulmonary TB in immunocompetent and immunocompromised patients, particularly for tuberculous meningitis, pericarditis, lymphadenitis, and intestinal TB. ? 2009 The British Infection Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561177 | ISSN: | 0163-4453 | DOI: | 10.1016/j.jinf.2009.10.001 | SDG/關鍵字: | gamma interferon; adolescent; adult; aged; article; bacterium culture; controlled study; diagnostic value; enzyme linked immunospot assay; extrapulmonary tuberculosis; female; human; immunocompromised patient; intestine tuberculosis; major clinical study; male; Mycobacterium tuberculosis; predictive validity; sensitivity and specificity; tuberculous lymphadenitis; tuberculous meningitis; tuberculous pericarditis; tuberculous peritonitis; Adolescent; Adult; Aged; Aged, 80 and over; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma; Male; Middle Aged; Sensitivity and Specificity; Tuberculosis; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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