https://scholars.lib.ntu.edu.tw/handle/123456789/561403
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang, Chia-Huang | en_US |
dc.contributor.author | Yu, Ching-Jung | en_US |
dc.contributor.author | Du, Jung-Chieh | en_US |
dc.contributor.author | Chiou, Hsien-Chih | en_US |
dc.contributor.author | Hou, Jia-Woei | en_US |
dc.contributor.author | Yang, Winnie | en_US |
dc.contributor.author | Chen, Chian-Feng | en_US |
dc.contributor.author | HSIN-CHANG CHEN | en_US |
dc.contributor.author | Chen, Ying-Sheue | en_US |
dc.contributor.author | Hwang, Betau | en_US |
dc.contributor.author | Chen, Mei-Lien | en_US |
dc.creator | Tang, Chuan Ho;Shi, Shu Han;Ching-Yu Lin;Wang, Wei Hsien | - |
dc.date.accessioned | 2021-05-19T02:17:41Z | - |
dc.date.available | 2021-05-19T02:17:41Z | - |
dc.date.issued | 2021-06-15 | - |
dc.identifier.issn | 00489697 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/561403 | - |
dc.description.abstract | This study will help to clarify the relationship between organophosphate pesticides (OPs) and attention deficit/hyperactivity disorder (ADHD) related to oxidative stress and paraoxonases (PON) polymorphisms to further characterize the gene-environment interaction. This case-control study enrolled 85 children with ADHD and 96 control subjects. Urinary OP levels were analyzed by using gas chromatography-mass spectrometry (GC-MS). Oxidative stress biomarkers, such as 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2-Gua), 8-iso-prostaglandin F2α (8-iso-PGF2α), and 4-hydroxy-2-nonenoic acid-mercapturic acid (HNE-MA), were analyzed by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S) were calculated to evaluate the additive interactions between OP exposure and PON genetic polymorphism on ADHD. A causal mediation analysis was conducted to clarify the mediation effects of oxidative stress due to OP exposure on ADHD. Children with ADHD had significantly higher DMP (238.95 nmol/g cre. vs. 164.83 nmol/g cre., p value = 0.01) and HNE-MA (30.75 μg/g cre. vs. 18.41 μg/g cre., p value<0.01) concentrations than control children. Children who carried the PON1 GG genotype (rs705379) had low urinary DMP levels, and the level increased with increasing numbers of allele variants. The risk for developing ADHD reached 2.06-fold (OR = 2.06, 95% CI:1.23-3.44) and 1.43-fold (OR = 1.45, 95% CI:1.04-2.03) when the DMP and HNE-MA levels increased by 1 natural log of the concentration, respectively. The estimated AP value was 0.66 (95% CI: 0.17-1.15), indicating that 66% of ADHD cases in DMP-exposed children with the PON1 CT/TT (rs705381) genotype were due to gene-environment interactions. No significant mediation of HNE-MA was observed between DMP exposure and the risk of ADHD. The estimated proportion mediated was only 7.0% (95% CI: -0.08-0.46). This research suggests the role of OP exposure in the occurrence of ADHD after adjusting for covariates. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | The Science of the total environment | en_US |
dc.subject | Additive interaction; Attention deficit/hyperactivity disorder; Organophosphate pesticides; Oxidative stress; Paraoxonases | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Biomarkers; Gas chromatography; Genes; Liquid chromatography; Mass spectrometry; Pesticides; Attention deficit; Case-control study; Gene-environment interaction; Genetic polymorphisms; Liquid chromatography tandem mass spectrometry (LC MS/MS); Mediation a | - |
dc.title | The associations among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of paraoxonases in children with attention deficit/hyperactivity disorder | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.scitotenv.2021.145604 | - |
dc.identifier.pmid | 33592467 | - |
dc.identifier.scopus | 2-s2.0-85100627007 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85100627007 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100627007&doi=10.1016%2fj.scitotenv.2021.145604&partnerID=40&md5=45628fcc80397406b89495573c4ba638 | - |
dc.relation.journalvolume | 773 | en_US |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0003-4879-3639 | - |
顯示於: | 食品安全與健康研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。