https://scholars.lib.ntu.edu.tw/handle/123456789/561834
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | White R.J. | en_US |
dc.contributor.author | Jerjes-Sanchez C. | en_US |
dc.contributor.author | Meyer G.M.B. | en_US |
dc.contributor.author | Pulido T. | en_US |
dc.contributor.author | Sepulveda P. | en_US |
dc.contributor.author | Wang K.Y. | en_US |
dc.contributor.author | Gr?nig E. | en_US |
dc.contributor.author | Hiremath S. | en_US |
dc.contributor.author | Yu Z. | en_US |
dc.contributor.author | Zhang G. | en_US |
dc.contributor.author | Yip W.L.J. | en_US |
dc.contributor.author | Zhang S. | en_US |
dc.contributor.author | Khan A. | en_US |
dc.contributor.author | Deng C.Q. | en_US |
dc.contributor.author | Grover R. | en_US |
dc.contributor.author | Tapson V.F. | en_US |
dc.contributor.author | Svetliza G.N. | en_US |
dc.contributor.author | Lescano A.J. | en_US |
dc.contributor.author | Bortman G.R. | en_US |
dc.contributor.author | Diez F.A. | en_US |
dc.contributor.author | Botta C.E. | en_US |
dc.contributor.author | Fitzgerald J. | en_US |
dc.contributor.author | Feenstra E. | en_US |
dc.contributor.author | Kermeen F.D. | en_US |
dc.contributor.author | Keogh A.M. | en_US |
dc.contributor.author | Williams T.J. | en_US |
dc.contributor.author | Yousseff P.P. | en_US |
dc.contributor.author | Ng B.J.-H. | en_US |
dc.contributor.author | Smallwood D.M. | en_US |
dc.contributor.author | Dwyer N.B. | en_US |
dc.contributor.author | Brown M.R. | en_US |
dc.contributor.author | Lang I.M. | en_US |
dc.contributor.author | Steringer-Mascherbauer R. | en_US |
dc.contributor.author | Arakaki J.O. | en_US |
dc.contributor.author | Campos F. | en_US |
dc.contributor.author | De Amorim Correa R. | en_US |
dc.contributor.author | De Souza R. | en_US |
dc.contributor.author | Meyer G.M.B. | en_US |
dc.contributor.author | Moreira M.C. | en_US |
dc.contributor.author | Yoo H. | en_US |
dc.contributor.author | Lapa M.S. | en_US |
dc.contributor.author | Swiston J. | en_US |
dc.contributor.author | Hirani N. | en_US |
dc.contributor.author | Mehta S. | en_US |
dc.contributor.author | Michelakis E. | en_US |
dc.contributor.author | Sepulveda P. | en_US |
dc.contributor.author | Zagolin M. | en_US |
dc.contributor.author | Liu J. | en_US |
dc.contributor.author | Zhang S. | en_US |
dc.contributor.author | Pan L. | en_US |
dc.contributor.author | Chunde B. | en_US |
dc.contributor.author | Qun Y. | en_US |
dc.contributor.author | Cheng X. | en_US |
dc.contributor.author | Yu Z. | en_US |
dc.contributor.author | Li X. | en_US |
dc.contributor.author | Hua Y. | en_US |
dc.contributor.author | Zhang G. | en_US |
dc.contributor.author | Zhu X. | en_US |
dc.contributor.author | Chen Y. | en_US |
dc.contributor.author | Cheng Z. | en_US |
dc.contributor.author | Yang Y. | en_US |
dc.contributor.author | Zhou D. | en_US |
dc.contributor.author | Shen J. | en_US |
dc.contributor.author | Nielsen-Kudsk J.E. | en_US |
dc.contributor.author | Carlsen J. | en_US |
dc.contributor.author | Bourdin A. | en_US |
dc.contributor.author | Hachulla E. | en_US |
dc.contributor.author | Dromer C. | en_US |
dc.contributor.author | Chaouat A. | en_US |
dc.contributor.author | Reynaud-Gauber M. | en_US |
dc.contributor.author | Seronde M.-F. | en_US |
dc.contributor.author | Klose H. | en_US |
dc.contributor.author | Halank M. | en_US |
dc.contributor.author | Hoffken G. | en_US |
dc.contributor.author | Ewert R. | en_US |
dc.contributor.author | Rosenkranz S. | en_US |
dc.contributor.author | Grunig E. | en_US |
dc.contributor.author | Kruger U. | en_US |
dc.contributor.author | Kronsbein J. | en_US |
dc.contributor.author | Hauptmeier B.M. | en_US |
dc.contributor.author | Koch A. | en_US |
dc.contributor.author | Held M. | en_US |
dc.contributor.author | Lange T.J. | en_US |
dc.contributor.author | Neurohr C. | en_US |
dc.contributor.author | Wilkens H. | en_US |
dc.contributor.author | Wirtz H. | en_US |
dc.contributor.author | Konstantinides S. | en_US |
dc.contributor.author | Argyropoulou-Pataka P. | en_US |
dc.contributor.author | Orfanos S. | en_US |
dc.contributor.author | Hiremath S. | en_US |
dc.contributor.author | Kerkar P.G. | en_US |
dc.contributor.author | Suresh P.V. | en_US |
dc.contributor.author | Baxi H.A. | en_US |
dc.contributor.author | Oomman A. | en_US |
dc.contributor.author | Abhaichand R.K. | en_US |
dc.contributor.author | Edla Kumar P.K. | en_US |
dc.contributor.author | Chopra V. | en_US |
dc.contributor.author | Mehrotra R. | en_US |
dc.contributor.author | Rajput R.K. | en_US |
dc.contributor.author | Sawhney J.S. | en_US |
dc.contributor.author | Bimalendu S. | en_US |
dc.contributor.author | Sharma K.H. | en_US |
dc.contributor.author | Srinivasa Sastry B.K. | en_US |
dc.contributor.author | Kramer M.R. | en_US |
dc.contributor.author | Segel M.J. | en_US |
dc.contributor.author | Ben-Dov I. | en_US |
dc.contributor.author | Berkman N. | en_US |
dc.contributor.author | Yigla M. | en_US |
dc.contributor.author | Adir Y. | en_US |
dc.contributor.author | D'Alto M. | en_US |
dc.contributor.author | Vizza C.D. | en_US |
dc.contributor.author | Scelsi L. | en_US |
dc.contributor.author | Vitulo P. | en_US |
dc.contributor.author | Pulido T.R. | en_US |
dc.contributor.author | Jerjes-Sanchez C. | en_US |
dc.contributor.author | Boonstra A. | en_US |
dc.contributor.author | Vonk M.C. | en_US |
dc.contributor.author | Sobkowicz B. | en_US |
dc.contributor.author | Mularek-Kubzdela T. | en_US |
dc.contributor.author | Torbicki A. | en_US |
dc.contributor.author | Podolec P. | en_US |
dc.contributor.author | Teik L.S. | en_US |
dc.contributor.author | Yip W.L.J. | en_US |
dc.contributor.author | Chang H.-J. | en_US |
dc.contributor.author | Kim H.-K. | en_US |
dc.contributor.author | Park J.-B. | en_US |
dc.contributor.author | Chang S.-A. | en_US |
dc.contributor.author | Kim D.-K. | en_US |
dc.contributor.author | Chung W.-J. | en_US |
dc.contributor.author | Song J.-M. | en_US |
dc.contributor.author | Nissell M. | en_US |
dc.contributor.author | Hjalmarsson C. | en_US |
dc.contributor.author | Rundqvist B. | en_US |
dc.contributor.author | Huang W.-C. | en_US |
dc.contributor.author | Cheng C.-C. | en_US |
dc.contributor.author | Hsu C.-H. | en_US |
dc.contributor.author | HSAO-HSUN HSU | en_US |
dc.contributor.author | Wang K.-Y. | en_US |
dc.contributor.author | Coghlan J.G. | en_US |
dc.contributor.author | Kiely D.G. | en_US |
dc.contributor.author | Pepke-Zaba J.W. | en_US |
dc.contributor.author | Lordan J.L. | en_US |
dc.contributor.author | Corris P.A. | en_US |
dc.contributor.author | Cadaret L. | en_US |
dc.contributor.author | Hansdottir S. | en_US |
dc.contributor.author | Oudiz R.J. | en_US |
dc.contributor.author | Badesch D.B. | en_US |
dc.contributor.author | Mathier M. | en_US |
dc.contributor.author | Schilz R. | en_US |
dc.contributor.author | Hill N. | en_US |
dc.contributor.author | Waxman A. | en_US |
dc.contributor.author | Markin C.J. | en_US |
dc.contributor.author | Zwicke D.L. | en_US |
dc.contributor.author | Fisher M. | en_US |
dc.contributor.author | Franco V. | en_US |
dc.contributor.author | Sood N. | en_US |
dc.contributor.author | Park M.H. | en_US |
dc.contributor.author | Allen R. | en_US |
dc.contributor.author | Feldman J.P. | en_US |
dc.contributor.author | Balasubramanian V. | en_US |
dc.contributor.author | Seeram V.K. | en_US |
dc.contributor.author | Bajwa A. | en_US |
dc.contributor.author | Thompson A.B. | en_US |
dc.contributor.author | III, Migliore C. | en_US |
dc.contributor.author | Elwing J. | en_US |
dc.contributor.author | McConnell J.W. | en_US |
dc.contributor.author | Mehta J.P. | en_US |
dc.contributor.author | Rahaghi F.F. | en_US |
dc.contributor.author | Rame J.E. | en_US |
dc.contributor.author | Khan A. | en_US |
dc.contributor.author | Patel B. | en_US |
dc.contributor.author | Oren R.M. | en_US |
dc.contributor.author | Klinger J.R. | en_US |
dc.contributor.author | Alnuaimat H. | en_US |
dc.contributor.author | Allen S. | en_US |
dc.contributor.author | Harvey W. | en_US |
dc.contributor.author | Eggert M.S. | en_US |
dc.contributor.author | Hage A. | en_US |
dc.contributor.author | Miller C.E. | en_US |
dc.contributor.author | Awdish R. | en_US |
dc.contributor.author | Cajigas H. | en_US |
dc.contributor.author | Grinnan D. | en_US |
dc.contributor.author | Trichon B.H. | en_US |
dc.contributor.author | McDonough C. | en_US |
dc.contributor.author | White R.J. | en_US |
dc.contributor.author | Rischard F. | en_US |
dc.creator | White R.J.;Jerjes-Sanchez C.;Meyer G.M.B.;Pulido T.;Sepulveda P.;Wang K.Y.;Gr?Nig E.;Hiremath S.;Yu Z.;Zhang G.;Yip W.L.J.;Zhang S.;Khan A.;Deng C.Q.;Grover R.;Tapson V.F.;Svetliza G.N.;Lescano A.J.;Bortman G.R.;Diez F.A.;Botta C.E.;Fitzgerald J.;Feenstra E.;Kermeen F.D.;Keogh A.M.;Williams T.J.;Yousseff P.P.;Ng B.J.-H.;Smallwood D.M.;Dwyer N.B.;Brown M.R.;Lang I.M.;Steringer-Mascherbauer R.;Arakaki J.O.;Campos F.;De Amorim Correa R.;De Souza R.;Meyer G.M.B.;Moreira M.C.;Yoo H.;Lapa M.S.;Swiston J.;Hirani N.;Mehta S.;Michelakis E.;Sepulveda P.;Zagolin M.;Liu J.;Zhang S.;Pan L.;Chunde B.;Qun Y.;Cheng X.;Yu Z.;Li X.;Hua Y.;Zhang G.;Zhu X.;Chen Y.;Cheng Z.;Yang Y.;Zhou D.;Shen J.;Nielsen-Kudsk J.E.;Carlsen J.;Bourdin A.;Hachulla E.;Dromer C.;Chaouat A.;Reynaud-Gauber M.;Seronde M.-F.;Klose H.;Halank M.;Hoffken G.;Ewert R.;Rosenkranz S.;Grunig E.;Kruger U.;Kronsbein J.;Hauptmeier B.M.;Koch A.;Held M.;Lange T.J.;Neurohr C.;Wilkens H.;Wirtz H.;Konstantinides S.;Argyropoulou-Pataka P.;Orfanos S.;Hiremath S.;Kerkar P.G.;Suresh P.V.;Baxi H.A.;Oomman A.;Abhaichand R.K.;Edla Kumar P.K.;Chopra V.;Mehrotra R.;Rajput R.K.;Sawhney J.S.;Bimalendu S.;Sharma K.H.;Srinivasa Sastry B.K.;Kramer M.R.;Segel M.J.;Ben-Dov I.;Berkman N.;Yigla M.;Adir Y.;D'Alto M.;Vizza C.D.;Scelsi L.;Vitulo P.;Pulido T.R.;Jerjes-Sanchez C.;Boonstra A.;Vonk M.C.;Sobkowicz B.;Mularek-Kubzdela T.;Torbicki A.;Podolec P.;Teik L.S.;Yip W.L.J.;Chang H.-J.;Kim H.-K.;Park J.-B.;Chang S.-A.;Kim D.-K.;Chung W.-J.;Song J.-M.;Nissell M.;Hjalmarsson C.;Rundqvist B.;Huang W.-C.;Cheng C.-C.;Hsu C.-H.;Hsao-Hsun Hsu;Wang K.-Y.;Coghlan J.G.;Kiely D.G.;Pepke-Zaba J.W.;Lordan J.L.;Corris P.A.;Cadaret L.;Hansdottir S.;Oudiz R.J.;Badesch D.B.;Mathier M.;Schilz R.;Hill N.;Waxman A.;Markin C.J.;Zwicke D.L.;Fisher M.;Franco V.;Sood N.;Park M.H.;Allen R.;Feldman J.P.;Balasubramanian V.;Seeram V.K.;Bajwa A.;Thompson A.B.;Iii, Migliore C.;Elwing J.;Mcconnell J.W.;Mehta J.P.;Rahaghi F.F.;Rame J.E.;Khan A.;Patel B.;Oren R.M.;Klinger J.R.;Alnuaimat H.;Allen S.;Harvey W.;Eggert M.S.;Hage A.;Miller C.E.;Awdish R.;Cajigas H.;Grinnan D.;Trichon B.H.;Mcdonough C.;White R.J.;Rischard F. | - |
dc.date.accessioned | 2021-05-24T03:41:38Z | - |
dc.date.available | 2021-05-24T03:41:38Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081891528&doi=10.1164%2frccm.201908-1640OC&partnerID=40&md5=7aa7fa326da1f6baad76d630834a75a7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/561834 | - |
dc.description.abstract | Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown. Objectives: To evaluate the effect of oral treprostinil compared with placebo on time to first adjudicated clinical worsening event in participants with PAH who recently began approved oral monotherapy. Methods: In this event-driven, double-blind study, we randomly allocated 690 participants (1:1 ratio) with PAH to receive placebo or oral treprostinil extended-release tablets three times daily. Eligible participants were using approved oral monotherapy for over 30 days before randomization and had a 6-minute-walk distance 150 m or greater. The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response. Measurements and Main Results: Clinical worsening occurred in 26% of the oral treprostinil group compared with 36% of placebo participants (hazard ratio, 0.74; 95% confidence interval, 0.56–0.97; P = 0.028). Key measures of disease status, including functional class, Borg dyspnea score, and N-terminal pro–brain natriuretic peptide, all favored oral treprostinil treatment at Week 24 and beyond. A noninvasive risk stratification analysis demonstrated that oral treprostinil–assigned participants had a substantially higher mortality risk at baseline but achieved a lower risk profile from Study Weeks 12–60. The most common adverse events in the oral treprostinil group were headache, diarrhea, flushing, nausea, and vomiting. Conclusions: In participants with PAH, addition of oral treprostinil to approved oral monotherapy reduced the risk of clinical worsening. Copyright ? 2020 by the American Thoracic Society | - |
dc.publisher | American Thoracic Society | - |
dc.relation.ispartof | American Journal of Respiratory and Critical Care Medicine | - |
dc.subject | Clinical study; Combination therapy; Oral treprostinil; Pulmonary arterial hypertension; Sequential therapy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amino terminal pro brain natriuretic peptide; prostacyclin; treprostinil; antihypertensive agent; placebo; prostacyclin; treprostinil; adult; Article; combination drug therapy; controlled study; death; diarrhea; disease exacerbation; double blind procedure; drug efficacy; drug withdrawal; dyspnea; female; headache; hospitalization; human; influenza; lung artery pressure; lung wedge pressure; major clinical study; male; middle aged; monotherapy; mortality risk; multicenter study; nausea and vomiting; outcome assessment; priority journal; pulmonary hypertension; randomized controlled trial; tablet; treatment response; walking distance; adolescent; aged; clinical trial; oral drug administration; pulmonary hypertension; young adult; Administration, Oral; Adolescent; Adult; Aged; Antihypertensive Agents; Double-Blind Method; Epoprostenol; Female; Humans; Male; Middle Aged; Placebos; Pulmonary Arterial Hypertension; Young Adult | - |
dc.title | Combination therapy with oral treprostinil for pulmonary arterial hypertension: A double-blind placebo-controlled clinical trial | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1164/rccm.201908-1640OC | - |
dc.identifier.pmid | 31765604 | - |
dc.identifier.scopus | 2-s2.0-85081891528 | - |
dc.relation.pages | 707-717 | - |
dc.relation.journalvolume | 201 | - |
dc.relation.journalissue | 6 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.orcid | 0000-0002-0376-1206 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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