https://scholars.lib.ntu.edu.tw/handle/123456789/562371
標題: | Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan | 其他標題: | 蛋白C缺乏及蛋白S缺乏是台灣中國人靜脈栓塞好發症最重要之危險因子 | 作者: | MING-CHING SHEN Lin J.-S. WOEI TSAY |
關鍵字: | Chinese; Protein C deficiency; Protein S deficiency; Risk factor; Venous thrombophilia | 公開日期: | 2000 | 卷: | 99 | 期: | 5 | 起(迄)頁: | 447-452 | 來源出版物: | Thrombosis Research | 摘要: | The relative risks (odds ratio, OR) of various risk factors for venous thrombophilia, including sex, antithrombin III, protein C (PC), protein S (PS) and plasminogen deficiencies, and C677T homozygous mutation of methylenetetrahydrofolate reductase gene were assessed using age matched (±5 years) conditional logistic regression analysis in 116 Chinese venous thrombophilic patients (58 males; 58 females; mean age 47.5 ± 17.7 [SD] years) and 125 healthy controls (67 males; 58 females; mean age 45.5 ± 15.7 years). None of the patients had prothrombin G20210A and factor V Leiden mutation or an activated PC sensitivity ratio of less than 2. One hundred and five age-matched patients and 105 controls were entered in this analysis. Only PC and PS deficiencies were significantly associated with increased risk for the development of thrombosis with an OR of 10.6 (95% confidence interval 2.3-49.9, P = 0.0028) and 6.7 (2.7-16.5, P = 0.0001), respectively. The findings of this study suggest that PC deficiency and PS deficiency are the most important risk factors for thrombosis in Chinese venous thrombophilic patients. (C) 2000 Elsevier Science Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562371 http://ntur.lib.ntu.edu.tw//handle/246246/103275 |
ISSN: | 0049-3848 | DOI: | 10.1016/S0049-3848(00)00265-6 | SDG/關鍵字: | 5,10 methylenetetrahydrofolate reductase (FADH2); blood clotting factor 5; plasminogen; protein C; protein S; prothrombin; adult; article; controlled study; female; gene mutation; genetic analysis; human; major clinical study; male; priority journal; protein C deficiency; protein S deficiency; race difference; regression analysis; risk factor; sex difference; Taiwan; thrombophilia; thrombosis; Adult; Aged; Anticoagulants; Antithrombin III; Asian Continental Ancestry Group; Blood Coagulation Disorders; Family Health; Female; Fibrinolytic Agents; Humans; Logistic Models; Male; Middle Aged; Plasminogen; Protein C Deficiency; Protein S Deficiency; Risk Factors; Taiwan; Thrombophilia; Venous Thrombosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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