https://scholars.lib.ntu.edu.tw/handle/123456789/562383
Title: | A longitudinal study of immunological status in Chinese haemophiliacs: Importance of the heat viral inactivation of factor concentrates. II. Improvements of CD4/CD8 ratio after treatments with heat-inactivated factor concentrates | Authors: | MING-CHING SHEN Hu F.-C. Lin J.-S. Tsai W. Fon M.-F. Wang E.-C. |
Keywords: | Allogeneic proteins; CD4 cell count; CD4/CD8 ratio; Chinese haemophiliacs; Immunological abnormalities; Viral inactivation of factor concentrate | Issue Date: | 1998 | Journal Volume: | 4 | Journal Issue: | 1 | Start page/Pages: | 33-40 | Source: | Haemophilia | Abstract: | Screened and heated clotting factor concentrates of intermediate purity have been used in Taiwanese haemophiliacs since the end of 1986. A significant improvement of CD4/CD8 ratio during the years 1987-1989 as compared with those during the years 1984-1986 was observed in haemophilia A patients [mean±SD (median), 1.191±0.495 (1.163) vs. 0.880±0.325 (0.838), P=0.0020] who were seronegative for human immunodeficiency virus. Almost all patients received an increased amount of factor VIII concentrates and total plasma products since 1987. Multiple linear regression analysis for the association of CD4/CD8 ratio with changes in dosage of plasma products revealed that there was a significant positive association of CD4/CD8 ratio measured during 1987-1989 with dosage of factor VIII concentrate administered during 1984-1986 (P=0.0230), which is an indicator for changes in viral load, but not with changes in dosage of plasma products, which are indicators for changes in plasma protein intake. Our data indicate that immunological abnormalities after replacement therapy observed in haemophiliacs are mainly attributed to virus infection through infusion of factor concentrates, not to allogeneic proteins existing in plasma products. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562383 | ISSN: | 1351-8216 | DOI: | 10.1046/j.1365-2516.1998.00132.x | SDG/Keyword: | blood clotting factor 8; adolescent; adult; article; Asian; CD4 CD8 ratio; CD4 lymphocyte count; CD8+ T lymphocyte; child; drug effect; heat; hemophilia A; human; immunology; isolation and purification; longitudinal study; lymphocyte count; pathology; preschool child; serodiagnosis; statistical model; Taiwan; virus activation; Adolescent; Adult; Asian Continental Ancestry Group; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Child; Child, Preschool; Factor VIII; Heat; Hemophilia A; HIV Seronegativity; Humans; Linear Models; Longitudinal Studies; Lymphocyte Count; Taiwan; Virus Activation |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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